Background Breast cancer is a common and deadly disease that affects women worldwide. Despite advancements in research and treatment, breast cancer continues to be a significant health issue.Objective This study examined the potential of black soybean, commonly known as Sojae Semen Nigrum (SSN), in the prevention and therapy of breast cancer using a mix of data mining, network pharmacology, and docking analysis.Methods Molecular dynamic simulation studies and docking analysis supported the findings by confirming the bioactive compounds' efficient activity against potential target genes.Results The study discovered the top three significant compounds Pramoxine, Sapogenol C, and beta-sitosterol, that may change target genes involved in the etiology of breast cancer as well as proteins like AKT1, MAPK1, and MAPK3. The study's conclusions point to SSN as having potential multi-target pharmacological defenses against breast cancer, laying the groundwork for more experimental exploration.Conclusion The study's conclusion suggests that SSN may help certain people with breast cancer and might transform cancer treatment.