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P(v-a)CO2/C(a-v)O2-directed resuscitation does not improve prognosis compared with SvO2 in severe sepsis and septic shock: A prospective multicenter randomized controlled clinical study

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收录情况： ◇ SCIE

作者：
Su, Longxiang[1] * ; Tang, Bo[1] * ; Liu, Yaling[2] ; Zhou, Guanhua[3] ; Guo, Qinghua[3] ; He, Wei[4] ; Wang, Chunmei[5] ; Zhuang, Haizhou[6] ; Jiang, Li[7] ; Qin, Long[8] ; Deng, Qun[9] ; Shuai, Weizheng[10] ; Zhang, Lina[11] ; Wang, Xiaomeng[12] ; Su, Jie[13] ; Ma, Siqing[14] ; Liu, Dawei[1] ; Long, Yun[1,*1] ;
机构： [1]Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China [2]Department of Critical Care Medicine, Beijing Pinggu Hospital, Beijing 101200, China [3]Department of Critical Care Medicine, People's Hospital of Beijing Daxing District, Beijing 102628, China [4]Department of Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [5]Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [6]Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100009, China [7]Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, Beijing 100038, China [8]Department of Critical Care Medicine, Beijing Haidian Hospital, Beijing 100036, China [9]Department of Critical Care Medicine, Chinese PLA General Affiliated First Hospital, Beijing 100000, China [10]Department of Critical Care Medicine, PLA Navy General Hospital, Beijing 100048, China [11]Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China [12]Department of Critical Care Medicine, Xuzhou Central Hospital, Xuzhou 221009, China [13]Department of Critical Care Medicine, Hebei Province Medical University Affiliated Fourth Hospital, Shijiazhuang 050000, China [14]Department of Critical Care Medicine, Qinghai Province People's Hospital, Xining 810007, China
出处：
DOI： 10.1016/j.jcrc.2018.09.009
ISSN：

关键词： Sepsis Resuscitation P(v-a)CO2/C(a-v)O2 ScvO2 Outcome

摘要：
Purposes: The present study examined the value of P(v-a)CO2/C(a-v)O2 compared with ScvO2 as a target for clinical resuscitation of severe sepsis/septic shock. Materials and methods: 228 patients were randomly divided into a P(v-a)CO2/C(a-v)O2-targeted and a ScvO2-targeted therapy group. The effects on hemodynamics, interventional intensity, and outcome were recorded and analyzed. Results: The mean arterial pressure (MAP) of the P(v-a)CO2/C(a-v)O2-targeted therapy group was significantly higher at 3 h, 12 h, 24 h, and 3 days (P < .05). The P(v-a)CO2/C(a-v)O2 of the ScvO2-targeted therapy group was significantly higher at each time point after resuscitation (P< .05). However, the CVP, lactate, urine output, ScvO2, and P(v-a)CO2 were not significantly improved. The P(v-a)CO2/C(a-v)O2-targeted therapy group used a smaller fluid volume and required fewer red blood cell transfusions and vasoactive drugs, but these results were also not significant. There were no differences between 28-day and 60-day mortality, APACHE and SOFA scores, ICU length of stay, residence length of stay, number of days free of vasoactive drugs, or number of ventilator-free days. Post hoc tests revealed no significant differences between these two groups in 28-day survival. Conclusion: P(v-a)CO2/C(a-v)O2-directed resuscitation did not improve prognosis compared with ScvO2 in severe sepsis and septic shock. (C) 2018 Published by Elsevier Inc.

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 医学
小类 | 4 区 危重病医学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 危重病医学
JCR分区：
出版当年[2016]版：
Q2 CRITICAL CARE MEDICINE
最新[2023]版：
Q2 CRITICAL CARE MEDICINE

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China [*1]Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
推荐引用方式(GB/T 7714)：
Su Longxiang,Tang Bo,Liu Yaling,et al.P(v-a)CO2/C(a-v)O2-directed resuscitation does not improve prognosis compared with SvO2 in severe sepsis and septic shock: A prospective multicenter randomized controlled clinical study[J].JOURNAL OF CRITICAL CARE.2018,48:314-320.doi:10.1016/j.jcrc.2018.09.009.
APA：
Su, Longxiang,Tang, Bo,Liu, Yaling,Zhou, Guanhua,Guo, Qinghua...&Long, Yun.(2018).P(v-a)CO2/C(a-v)O2-directed resuscitation does not improve prognosis compared with SvO2 in severe sepsis and septic shock: A prospective multicenter randomized controlled clinical study.JOURNAL OF CRITICAL CARE,48,
MLA：
Su, Longxiang,et al."P(v-a)CO2/C(a-v)O2-directed resuscitation does not improve prognosis compared with SvO2 in severe sepsis and septic shock: A prospective multicenter randomized controlled clinical study".JOURNAL OF CRITICAL CARE 48.(2018):314-320

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