机构：[1]Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China[2]Department of Clinical Laboratory, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100000, China北京朝阳医院[3]Department of Clinical Laboratory, 302 Military Hospital of China, Peking University, Beijing 100039, China[4]Department of Clinical Laboratory, China-Japan Friendship Hospital, Peking University Health Science Center, Beijing University of Chinese Medicine, Beijing 100029, China[5]Department of Clinical Laboratory, Beijing Hospital, Peking University, Beijing 100730, China[6]Department of Clinical Laboratory, The General Hospital of PLA Rocket Force, Beijing 100088, China[7]Department of Clinical Laboratory, Aerospace Center Hospital, Peking University, Beijing 100049, China[8]Department of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China医技科室检验科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[9]Department of Clinical Laboratory, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China[10]Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing 100029, China首都医科大学附属安贞医院[11]Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[12]Department of Clinical Laboratory, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China[13]Department of Clinical Laboratory, Peking University Cancer Hospital & Institute, Peking University, Beijing 100142, China[14]Department of Clinical Laboratory, First Affiliated Hospital of Chinese PLA General Hospital, The Second Military Medical University, Beijing 100048, China[15]Department of Infection Control, First Affiliated Hospital of Chinese PLA General Hospital, The Second Military Medical University, Beijing 100048, China[16]Department of Clinical Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China[17]Department of Clinical Laboratory, Children’s Hospital, Capital institute of Pediatrics, Beijing 100020, China首都儿科研究所[18]Department of Clinical Laboratory, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China[19]Department of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China首都医科大学附属北京友谊医院[20]State Key Laboratory of Infectious Disease Prevention & Control, Collaborative Innovation Centre for Diagnosis & Treatment of Infectious Diseases, National Institute for Communicable Disease Control & Prevention, Chinese Center for Disease Control & Prevention, Beijing 102206, China[21]Department of Clinical Laboratory, Shougang Hospital, Peking University, Beijing 100144, China[22]Department of Clinical Laboratory, FuXing Hospital, Capital Medical University, Beijing 100038, China[23]Department of Clinical Laboratory, Second Hospital of Armed Police Beijing Office, Jiangxi University of Traditional Chinese Medicine, Beijing 100037, China[24]Department of Clinical Laboratory, FengTai Hospital, Capital Medical University, Beijing 100070, China[25]Department of Clinical Laboratory, China MeiTan General Hospital, North China Coal Medical University, Beijing 100028, China[26]Department of Clinical Laboratory, Beijing ShiJiTan Hospital, Capital Medical University, Beijing 100038, China[27]Department of Clinical Laboratory, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China[28]Department of Clinical Laboratory, State Grid Corporation of China Beijing Electric Power Hospital, Capital Medical University, Beijing 100073, China[29]Department of Clinical Laboratory, Beijing TianTan Hospital, Capital Medical University, Beijing 100050, China首都医科大学附属天坛医院[30]Department of Clinical Laboratory, DongZhiMen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China[31]Department of Infectious Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China[32]Departments of Laboratory Medicine & Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 100, Taiwan
Aim: To investigate the species distribution and antifungal susceptibility profiles of yeast isolates causing invasive infections across Beijing. Materials & methods: A total of 1201 yeast isolates recovered from blood and other sterile body fluids were correctly identified by matrix-assisted laser desorption/ionization TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed according to the Clinical and Laboratory Standards Institute broth microdilution method. Results: Candida (95.5%) remained the most common yeast species isolated; Candida albicans (38.8%) and Candida parapsilosis (22.6%) were the leading species of candidemia. Azole resistances were mainly observed in Candida glabrata and Candida tropicalis isolates. Conclusion: This study outlined the epidemiologic data of invasive yeast infections and highlighted the need for continuous monitoring of azole resistances among C. glabrata and C. tropicalis isolates in Beijing.
基金：
Special Research Foundation for Capital Medical Development: Epidemiology and In vitro Antifungal Susceptibility of Yeast Species Causing Invasive Fungal Infections in Beijing (Grant No. 2011-4001-09; http://www.bjhbkj.com/; identify author: YC Xu).
