机构：[1]Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China临床科室神经外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China首都医科大学附属北京同仁医院研究所眼科研究所[4]Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[5]Department of Ophthalmology, Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China[6]Eye center, New York Eye and Ear Infirmary, New York 10003, USA[7]Department of Endoscopic and Microinvasive Neurosurgery, Beijing Neurosurgery Institute, Beijing Tiantian Hospital, Capital Medical University, Beijing 100050, China[8]Institute of Medical Psychology, Medical Faculty, Otto-v.-Guericke University of Magdeburg, Magdeburg 39120, Germany
To determine the interdependence of intracranial pressure (ICP) and intraocular pressure (IOP) and how it affects optic nerve pressures, eight normal dogs were examined using pressure-sensing probes implanted into the left ventricle, lumbar cistern, optic nerve subarachnoid space in the left eye, and anterior chamber in the left eye. This allowed ICP, lumbar cistern pressure (LCP), optic nerve subarachnoid space pressure (ONSP) and IOP to be simultaneously recorded. After establishing baseline pressure levels, pressure changes that resulted from lowering ICP (via shunting cerebrospinal fluid (CSF) from the ventricle) were recorded. At baseline, all examined pressures were different (ICP>LCP>ONSP), but correlated (P<0.001). As ICP was lowered during CSF shunting, IOP also dropped in a parallel time course so that the trans-lamina cribrosa gradient (TLPG) remained stable (ICP-IOP dependent zone). However, once ICP fell below a critical breakpoint, ICP and IOP became uncoupled and TLPG changed as ICP declined (ICP-IOP independent zone). The optic nerve pressure gradient (ONPG) and trans-optic nerve pressure gradient (TOPG) increased linearly as ICP decreased through both the ICP-IOP dependent and independent zones. We conclude that ICP and IOP are coupled in a specific pressure range, but when ICP drops below a critical point, IOP and ICP become uncoupled and TLPG increases. When ICP drops, a rise in the ONPG and TOPG creates more pressure and reduces CSF flow around the optic nerve. This change may play a role in the development and progression of various ophthalmic and neurological diseases, including glaucoma.
基金：
This study was supported by the National Natural
Science Foundation of China (81271005, 81300767), Beijing Natural
Science Foundation (7122038), and two separate donations by the China
Health and Medical Development Foundation. B.A.S. was supported by the
BMBF network ERA-net Neuron “Restoration of Vision after Stroke
(REVIS)” (BMBF 01EW1210), and by the “Hai-ju” Beijing Overseas
Talents Program. Ruowu Hou was supported by the Beijing Tongren Hospital Foundation (2015-YJJ-GGL-013).
第一作者机构：[1]Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
共同第一作者：
通讯作者：
通讯机构：[2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China[3]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Hou Ruowu,Zhang Zheng,Yang Diya,et al.Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study[J].SCIENCE CHINA-LIFE SCIENCES.2016,59(5):495-503.doi:10.1007/s11427-016-5022-9.
APA：
Hou, Ruowu,Zhang, Zheng,Yang, Diya,Wang, Huaizhou,Chen, Weiwei...&Wang, Ningli.(2016).Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study.SCIENCE CHINA-LIFE SCIENCES,59,(5)
MLA：
Hou, Ruowu,et al."Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study".SCIENCE CHINA-LIFE SCIENCES 59..5(2016):495-503
