机构：[1]Capital Med Univ, ICU Fu Xing Hosp, Dept Crit Care Med, Beijing 10038, Peoples R China[2]Capital Med Univ, ICU Beijing Ditan Hosp, Dept Crit Care Med, Beijing 100015, Peoples R China[3]MICU Peking Union Med Coll Hosp, Med Intens Care Unit, Beijing 100730, Peoples R China[4]ICU Peking Univ, Hosp 3, Dept Crit Care Med, Beijing 100191, Peoples R China[5]Capital Med Univ, ICU Beijing Friendship Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China首都医科大学附属北京友谊医院[6]ICU China Japan Friendship Hosp, Dept Crit Care Med, Beijing 100029, Peoples R China[7]Gen Hosp Peoples Liberat Army, ICU Affiliated Hosp 1, Dept Crit Care Med, Beijing 100048, Peoples R China[8]Capital Med Univ, ICU Beijing Shijitan Hosp, Dept Crit Care Med, Beijing 100038, Peoples R China[9]ICU 309th Hosp Chinese Peoples Liberat Army, Dept Crit Care Med, Beijing 100094, Peoples R China[10]Capital Med Univ, SICU Xuan Wu Hosp, Surg Intens Care Unit, Beijing 100053, Peoples R China首都医科大学宣武医院[11]Capital Med Univ, ICU Beijing Tong Ren Hosp, Dept Crit Care Med, Beijing 100730, Peoples R China临床科室重症医学科-中心ICU首都医科大学附属北京同仁医院首都医科大学附属同仁医院[12]Capital Med Univ, ICU Beijing Tian Tan Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China[13]ICU Beijing Haidian Hosp, Dept Crit Care Med, Beijing 100080, Peoples R China[14]China Japan Friendship Hosp, Dept Resp, Beijing 100029, Peoples R China[15]Capital Med Univ, SICU Beijing Chao Yang Hosp, Surg Intens Care Unit, Beijing 100020, Peoples R China北京朝阳医院
Purpose: A proposal was made at the International Consensus Conference to classify weaning of patients in intensive care units from mechanical ventilation into simple, difficult, and prolonged weaning groups based on the difficulty and length of the weaning process. The objective of the present study was to determine the incidence and outcome of weaning according to these new categories. Methods: We examined the weaning of patients in intensive care units from mechanical ventilation in a prospective multicenter cohort study. Results: In total, 343 patients were included in the final analysis. Simple, difficult, and prolonged weaning occurred in 200 (58%), 99 (29%), and 44 (13%) patients, respectively. Hospital mortality rates were higher for patients in the prolonged weaning group than in the simple and difficult weaning groups. Multivariate analysis revealed that a lower Glasgow Coma Scale score (P < .014) and hypercapnia at the beginning of the first spontaneous breathing trial (P = .038) were independent predictors of prolonged weaning. Conclusions: Patients who experienced prolonged weaning had significantly higher mortality rates than patients who experienced either simple or difficult weaning. A lower Glasgow Coma Scale score and hypercapnia at the beginning of the weaning process were independent risk factors for prolonged weaning. (C) 2015 Elsevier Inc. All rights reserved.
基金：
Research Fund of Capital Medical Development [H020920020530]
第一作者机构：[1]Capital Med Univ, ICU Fu Xing Hosp, Dept Crit Care Med, Beijing 10038, Peoples R China[2]Capital Med Univ, ICU Beijing Ditan Hosp, Dept Crit Care Med, Beijing 100015, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, ICU Fu Xing Hosp, Dept Crit Care Med, Beijing 10038, Peoples R China[*1]Capital Med Univ, Fu Xing Hosp, 20 Fuxingmenwai St, Beijing 10038, Peoples R China
推荐引用方式(GB/T 7714)：
Pu Lin,Zhu Bo,Jiang Li,et al.Weaning critically ill patients from mechanical ventilation: A prospective cohort study[J].JOURNAL OF CRITICAL CARE.2015,30(4):doi:10.1016/j.jcrc.2015.04.001.
APA：
Pu, Lin,Zhu, Bo,Jiang, Li,Du, Bin,Zhu, Xi...&Xi, XiuMing.(2015).Weaning critically ill patients from mechanical ventilation: A prospective cohort study.JOURNAL OF CRITICAL CARE,30,(4)
MLA：
Pu, Lin,et al."Weaning critically ill patients from mechanical ventilation: A prospective cohort study".JOURNAL OF CRITICAL CARE 30..4(2015)
