国家重点研发计划(2018YFC2001500)%国家自然科学基金重大研究计划项目(91749204)%国家自然科学基金(81771491)%上海市卫生系统优秀学科带头人计划(2017BR011)%National Key Research and Development Program of China(2018YFC2001500)%National Natural Science Foundation Key Research Program of China(91749204)%National Natural Science Foundation of China(81771491)%Project of Shanghai Subject Chief Scientist(2017BR011)