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Current status of diagnosis and treatment of bladder cancer in China - Analyses of Chinese Bladder Cancer Consortium database

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机构: [a]Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China [b]Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China [c]Department of Urology, Fujian Medical University Union Hospital, Fuzhou, China [d]Department of Urology, General Hospital of Ningxia Medical University, Yinchuan, China [e]Department of Urology, Peking University Third Hospital, Beijing, China [f]Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China [g]Department of Urology, The Xinjiang Uygur Autonomous Region People’s Hospital, Uygur, China [h]Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China [i]Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China [j]Department of Urology, Southwest Hospital, Third Military Medical University, Chongqing, China [k]Department of Urology, Daping Hospital, Third Military Medical University, Chongqing, China [l]Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China [m]Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [n]Department of Urology, Peking University First Hospital, Beijing, China [o]Department of Urology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China [p]Department of Urology, China Japan Friendship Hospital of Jilin University, Changchun, China [q]Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China [r]Department of Urology, Wuhan General Hospital of Guangzhou Military, Wuhan, China [s]Department of Urology, The First Affiliated Hospital of Shanxi University, Taiyuan, China [t]Department of Urology, Qilu Hospital of Shandong University, Jinan, China [u]Department of Urology, West China Hospital, Sichuan University, Chengdu, China [v]Department of Urology, The Second Affiliated Hospital of Tianjin Medical University, Tianjin, China [w]Department of Urology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [x]Department of Urology, Lanzhou University Second Hospital, Lanzhou, China [y]Department of Urology, Xiangya Hospital Central South University, Changsha, China [z]Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China [aa]Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China [ab]Department of Urology, Guizhou Provincial People’s Hospital, Guiyang, China [ac]Department of Urology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China [ad]Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, China [ae]Department of Urology, Beijing Hospital, Beijing, China [af]Department of Urology, Peking University, Wu Jieping Urology Center, Beijing, China [ag]Department of Urology, The First Hospital of Jilin University, Changchun, China [ah]Department of Urology, The First Hospital of China Medical University, Shenyang, China [ai]Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, China [aj]Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China [ak]Department of Urology, Jiangsu Province Hospital, Nanjing, China [al]Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [am]Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China [an]Department of Urology, Chinese PLA General Hospital, Beijing, China [ao]Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China [ap]Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China [aq]Department of Urology, Hainan General Hospital, Haikou, China [ar]Department of Urology, Peking Union Medical College Hospital, Beijing, China
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关键词: Bladder cancer Diagnosis Treatment

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Objective: To investigate current status of diagnosis and treatment of bladder cancer in China. Methods: A database was generated by Chinese Bladder Cancer Consortium (CBCC). From January 2007 to December 2012, 14,260 cases from 44 CBCC centers were included. Data of diagnosis, treatment and pathology were collected. Results: The average age was 63.5 year-old and most patients were male (84.3%). The most common histologic types were urothelial carcinoma (91.4%), adenocarcinoma (1.8%), and squamous carcinoma (1.9%). According to 1973 and 2004 WHO grading system, 42.0%, 41.0%, and 17.0% of patients were grade 1, 2, and 3, and 16.0%, 48.7%, and 35.3% of patients were papillary urothelial neoplasms of low malignant potential, low, and high grade, respectively. Non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC) were 25.2% and 74.1%, respectively (0.8% not clear). Carcinoma in situ was only 2.4%. Most patients were diagnosed by white-light cystoscopy with biopsy (74.3%). Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%, respectively. Diagnostic transurethral resection (TUR) provided detection rate of 16.9%. Most NMIBCs were treated with TUR (89.2%). After initial TUR, 2.6% accepted second TUR, and 45.7%, 69.9%, and 58.7% accepted immediate, induced, and maintenance chemotherapy instillation, respectively. Most MIBCs were treated with radical cystectomy (RC, 59.7%). Laparoscopic RCs were 35.1%, while open RC 63.4%. Extended and standard pelvic lymph node dissection were 7% and 66%, respectively. Three most common urinary diversions were orthotopic neobladder (44%), ileal conduit (31%), and ureterocutaneostomy (23%). Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18% of T3 and T4 patients accepted adjuvant chemotherapy. Conclusion: Disease characteristics are similar to international reports, while differences of diagnosis and treatment exist. This study can provide evidences for revisions of the guideline on bladder cancer in China. 2015 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier (Singapore) Pte Ltd. This is an open access article under the CC BY-NC-ND license.

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大类 | 3 区 医学
小类 | 4 区 泌尿学与肾脏学
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第一作者机构: [a]Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
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