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Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes.

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Lihua Zhu[1,2] * ; Zhi-Gang She[1,2] * ; Xu Cheng[1,2] * ; Juan-Juan Qin[1,2] * ; Xiao-Jing Zhang[1,2] * ; Jingjing Cai[3] ; Fang Lei[2] ; Haitao Wang[4] ; Jing Xie[1] ; Wenxin Wang[1,2] ; Haomiao Li[1,2] ; Peng Zhang[2,5] ; Xiaohui Song[2] ; Xi Chen[4] ; Mei Xiang[6] ; Chaozheng Zhang[2] ; Liangjie Bai[2] ; Da Xiang[2] ; Ming-Ming Chen[1,2] ; Yanqiong Liu[2] ; Youqin Yan[7] ; Mingyu Liu[8] ; Weiming Mao[9] ; Jinjing Zou[10] ; Liming Liu[11] ; Guohua Chen[12] ; Pengcheng Luo[13] ; Bing Xiao[14] ; Changjiang Zhang[1,15] ; Zixiong Zhang[15] ; Zhigang Lu[16] ; Junhai Wang[17] ; Haofeng Lu[18] ; Xigang Xia[19] ; Daihong Wang[20] ; Xiaofeng Liao[21] ; Gang Peng[22] ; Ping Ye[6] ; Jun Yang[23] ; Yufeng Yuan[4] ; Xiaodong Huang[24] ; Jiao Guo[25] ; Bing-Hong Zhang[26] ; Hongliang Li[1,2,5,27] ;
机构： [1]Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430072, China [2]Institute of Model Animal, Wuhan University, Wuhan 430072, China [3]Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410000, China [4]Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430072, China [5]Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan 430072, China [6]Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan430072, China [7]Wuhan Seventh Hospital, Wuhan 430072, China [8]The Ninth Hospital of Wuhan City, Wuhan 430072, China [9]Department of General Surgery, Huanggang Central Hospital, Huanggang 438000, China [10]Department of Pulmonary and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 430072, China [11]Department of General Surgery, Ezhou Central Hospital, Ezhou 436000, China [12]Department of Neurology, Wuhan First Hospital/Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan 430072, China [13]Department of Urology, Wuhan Third Hospital and Tongren Hospital of Wuhan University, Wuhan 430072, China [14]Department of Stomatology, Xiantao First People’s Hospital, Xiantao 433000, China [15]The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China [16]Department of Neurology, The First People’s Hospital of Jingmen affiliated to Hubei Minzu University, Jingmen 448000, China [17]Department of Orthopedics, The First People’s Hospital of Jingmen affiliated to Hubei Minzu University, Jingmen 448000 China [18]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Changjiang University, Jingzhou 434000, China [19]Department of Hepatobiliary Surgery, Jingzhou Central Hospital, Jingzhou 434000, China [20]Department of Hepatobiliary and Pancreatic Surgery, Xianning Central Hospital, Xianning 437000, China [21]Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441000, China [22]Department of Hepatobiliary and Pancreatic Surgery, Suizhou Central Hospital Affiliated to Hubei Medical College, Suizhou 441300, China [23]Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University and Yichang Central People’sHospital and Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, China [24]Department of Gastroenterology, Wuhan Third Hospital and Tongren Hospital of Wuhan University, Wuhan 430072, China [25]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine & Key Laboratory of Glucolipid MetabolicDisorder, Ministry of Education of China and Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong TCM KeyLaboratory for Metabolic Diseases, Guangzhou 510006, China [26]Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan 430072, China [27]Basic Medical School, Wuhan University, Wuhan 430072, China
出处：
DOI： 10.1016/j.cmet.2020.04.021
ISSN：

摘要：
Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D. Copyright © 2020 Elsevier Inc. All rights reserved.

基金：
National Key R&D Program of China (2016YFF0101504 to Z.-G.S.), the National Science Foundation of China (81630011 to H.L., 81970364 to Z.-G.S., 81970070 to X.-J.Z., 81970011 to P.Z., and 81870171 to J.C.), the Major Research Plan of the National Natural Science Foundation of China (91639304 to H.L.), the Hubei Science and Technology Support Project (2019BFC582 to H.L., 2018BEC473 to H.L., and 2017BEC001 to H.L), and Medical Flight Plan of Wuhan University.
语种：
外文
高被引：
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 生物
小类 | 1 区 细胞生物学 1 区 内分泌学与代谢
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学 1 区 内分泌学与代谢
JCR分区：
出版当年[2018]版：
Q1 ENDOCRINOLOGY & METABOLISM Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430072, China [2]Institute of Model Animal, Wuhan University, Wuhan 430072, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430072, China [2]Institute of Model Animal, Wuhan University, Wuhan 430072, China [5]Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan 430072, China [27]Basic Medical School, Wuhan University, Wuhan 430072, China
推荐引用方式(GB/T 7714)：
Lihua Zhu,Zhi-Gang She,Xu Cheng,et al.Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes.[J].CELL METABOLISM.2020,31(6):1068-+.doi:10.1016/j.cmet.2020.04.021.
APA：
Lihua Zhu,Zhi-Gang She,Xu Cheng,Juan-Juan Qin,Xiao-Jing Zhang...&Hongliang Li.(2020).Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes..CELL METABOLISM,31,(6)
MLA：
Lihua Zhu,et al."Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes.".CELL METABOLISM 31..6(2020):1068-+

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