This study investigated whether early intervention based on leukocyte count (WBC) of less than 2.85x10(9)/L obtained within 2h post-operatively may ameliorate the uroseptic shock induced by upper urinary tract endoscopic lithotripsy (UUTEL). Urosepsis was induced in 30 rabbits and assigned to three groups: Control-I, WBC-I, and Shock-I. Control-I: Non-intervention control. WBC-I: Immediate resuscitation when there was a drastic drop of WBC within 2h post-operatively but without signs or symptoms of shock. Shock-I: Resuscitation only when there were signs or symptoms of shock. In total, 107 patients whose WBC were less than 2.85x10(9)/L within 2h after UUTEL were retrospectively analyzed. Patients were assigned into two groups based on the time of the intervention. Shock-II included 59 patients who were started on the resuscitation bundle when there were signs or symptoms of shock. WBC-II included 48 patients who were started immediately on the resuscitation bundle when the WBC decreased drastically. All Control-I rabbits developed shock within 72h and died. None of the WBC-I rabbits developed shock and all survived for 72h. In total, 60% of Shock-I died within 72h. Overall, 43 patients in Shock-II and six patients in WBC-II experienced uroseptic shock. The average lengths of hospitalization for Shock-II and WBC-II were 17.8 +/- 9.7days and 7 +/- 4.2days, respectively. Six patients in the Shock-II and none in WBC-II died of the uroseptic shock. Early intervention based on WBC measured within 2h post-operatively might avert the uroseptic shock induced by UUTEL.
基金：
Medical and Health science and Technology project of Zhejiang Province [2015KYB222] Funding Source: Medline; Science and Technology Department of Zhejiang Province [2016F81G2010012] Funding Source: Medline
第一作者机构：[1]Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Urol, Hangzhou 310016, Zhejiang, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wu Haiyang,Wang Zhenghui,Zhu Shibin,et al.Uroseptic Shock Can Be Reversed by Early Intervention Based on Leukocyte Count 2h Post-operation: Animal Model and Multicenter Clinical Cohort Study[J].INFLAMMATION.2018,41(5):1835-1841.doi:10.1007/s10753-018-0826-3.
APA：
Wu, Haiyang,Wang, Zhenghui,Zhu, Shibin,Rao, Dapang,Hu, Linyun...&Li, Gonghui.(2018).Uroseptic Shock Can Be Reversed by Early Intervention Based on Leukocyte Count 2h Post-operation: Animal Model and Multicenter Clinical Cohort Study.INFLAMMATION,41,(5)
MLA：
Wu, Haiyang,et al."Uroseptic Shock Can Be Reversed by Early Intervention Based on Leukocyte Count 2h Post-operation: Animal Model and Multicenter Clinical Cohort Study".INFLAMMATION 41..5(2018):1835-1841
