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Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease

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作者：
Peizeng Yang[1,*1] * ; Yuanyuan Zhong[1] ; Liping Du[1] ; Wei Chi[2] ; Ling Chen[3] ; Rui Zhang[3] ; Meifen Zhang[4] ; Hong Wang[5] ; Hong Lu[6] ; Liu Yang[7] ; Wenjuan Zhuang[8] ; Yan Yang[9] ; Lin Xing[10] ; Lei Feng[11] ; Zhengxuan Jiang[12] ; Xiaomin Zhang[13] ; Yuqin Wang[14] ; Hui Zhong[15] ; Liqiong Jiang[16] ; Changlin Zhao[17] ; Fuzhen Li[18] ; Shuang Cao[19] ; Xiaoli Liu[20] ; Xuan Chen[21] ; Yanyun Shi[22] ; Weizhong Zhao[23] ; Aize Kijlstra[24] ;
机构： [1]The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute,Chongqing, People’s Republic of China [2]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People’s Republic of China [3]The Eye and ENT Hospital of Fudan University, Shanghai, People’s Republic of China [4]Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China [5]Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China [6]Department of Ophthalmology, Beijing Chao-Yang Hospital of Capital Medical University, Beijing, People’s Republic of China [7]Department of Ophthalmology, Peking University First Hospital, Beijing, People’s Republic of China [8]Department of Ophthalmology, Ningxia People’s Hospital, Yinchuan, People’s Republic of China [9]Department of Ophthalmology, the Second Xiangya Hospital of Central South University, Changsha, People’s Republic of China [10]Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China [11]Department of Ophthalmology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People’s Republic of China [12]Department of Ophthalmology, the Second Hospital of Anhui Medical University, Hefei, People’s Republic of China [13]Tianjin Medical University Eye Hospital, Tianjin, People’s Republic of China [14]The Eye Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China [15]Department of Ophthalmology, Shenzhen Children’s Hospital, Shenzhen, People’s Republic of China [16]Shenzhen Eye Hospital, Shenzhen Key Ophthalmic Laboratory, the Second Affiliated Hospital of Jinan University, Shenzhen, People’s Republic of China [17]Department of Ophthalmology, Jinling Hospital, Medical School of Nanjing University, Nanjing, People’s Republic of China [18]Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, People’s Republic of China [19]Department of Ophthalmology, Xi’an No. 4 Hospital, Xi’an, People’s Republic of China [20]Ophthalmic Center of the Second Hospital, Jilin University, Changchun, People’s Republic of China [21]Department of Ophthalmology, the Second People’s Hospital of Jinan City, Jinan, People’s Republic of China [22]Shanxi Eye Hospital, Taiyuan, People’s Republic of China [23]College of Information Engineering, Xiangtan University, Xiangtan, People’s Republic of China [24]University Eye Clinic Maastricht, Maastricht, Limburg, the Netherlands
出处：
DOI： 10.1001/jamaophthalmol.2018.2664
ISSN：

摘要：
IMPORTANCE To our knowledge, a set of well-defined diagnostic criteria is not yet developed for the diagnosis of Vogt-Koyanagi-Harada (VKH) disease. OBJECTIVE To develop and evaluate a set of diagnostic criteria for VKH disease using data from Chinese patients. DESIGN, SETTING, AND PARTICIPANTS This case-control study reviewed medical records of patients from a tertiary referral center between October 2011 and October 2016. Data from 634 patients with VKH disease and 623 patients with non-VKH uveitis from southern China were used to develop the Diagnostic Criteria for VKH Disease (DCV). Data from an additional group of 537 patients with a definite VKH disease diagnosis and 525 patients with non-VKH uveitis from northern China were used to evaluate the diagnostic criteria. MAIN OUTCOMES AND MEASURES Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristic. RESULTS Of the 1257 patients used to construct the DCV, 665 (52.9%) were male, and the mean (SD) age at disease onset was 38.6 (13.6) years. The 3-class model and 21 clinical findings were selected by latent class analysis. Variables with a high positive rate in the early-phase or late-phase VKH group or high specificity constituted essential parameters. Constellations of these essential parameters constructed the DCV. The sensitivity and NPV of the DCV were higher than those of the Revised Diagnostic Criteria for VKH Disease (RDC) (sensitivity: 94.6%vs 71.9%; difference, 22.7%; 95%CI, 18.5-27.0; NPV: 94.3%vs 76.6%; difference, 17.7%; 95%CI, 13.9-21.5). The specificity and PPV of the DCV were not different from that of the RDC (specificity: 92.2%vs 93.9%; difference, 1.7%; 95%CI, -1.4 to 4.8; PPV: 89.3%vs 92.3%; difference, 3.0%; 95%CI, -1.4 to 4.8). The area under the receiver operating characteristic curve of the DCV and the RDC were 0.934 (95%CI, 0.917-0.951) and 0.829 (95%CI, 0.803-0.855), respectively. CONCLUSIONS AND RELEVANCE The DCV were developed and evaluated using data from Chinese patients with VKH disease and showed a high sensitivity, NPV, and area under the receiver operating characteristic curve in comparison with the RDC. However, they were developed using a retrospective analysis and should be evaluated in prospective studies in other racial/ethnic populations. © 2018 American Medical Association. All rights reserved.

基金：
Funding/Support: This work was supported by grants 2016YFC0904000, 2016YFC0904001, 2016YFC0904002, and 2016YFC0904003 from the National Key R&D Program of China, CSTC grant 2008CA5003 from the Chongqing Key Laboratory of Ophthalmology, grant cstc2014pt-sy10002 from the Chongqing Science & Technology Platform and Base Construction Program, and grant cstc2017shmsA0503 from the Natural Science Foundation Project of Chongqing.
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外文
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中科院(CAS)分区：
出版当年[2017]版：
大类 | 2 区 医学
小类 | 1 区 眼科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
JCR分区：
出版当年[2016]版：
Q1 OPHTHALMOLOGY
最新[2023]版：
Q1 OPHTHALMOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute,Chongqing, People’s Republic of China [*1]the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Youyi Road 1, Chongqing 400016, People’s Republic of China
通讯作者：
通讯机构： [1]The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute,Chongqing, People’s Republic of China [*1]the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Youyi Road 1, Chongqing 400016, People’s Republic of China
推荐引用方式(GB/T 7714)：
Peizeng Yang,Yuanyuan Zhong,Liping Du,et al.Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease[J].JAMA OPHTHALMOLOGY.2018,136(9):1025-1031.doi:10.1001/jamaophthalmol.2018.2664.
APA：
Peizeng Yang,Yuanyuan Zhong,Liping Du,Wei Chi,Ling Chen...&Aize Kijlstra.(2018).Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease.JAMA OPHTHALMOLOGY,136,(9)
MLA：
Peizeng Yang,et al."Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease".JAMA OPHTHALMOLOGY 136..9(2018):1025-1031

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