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Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Wang, Li-Dong[1,2] * ; Zhou, Fu-You[2,3] ; Li, Xue-Min[2,4] ; Sun, Liang-Dan[5] ; Song, Xin[1,2] ; Jin, Yan[1] ; Li, Jiang-Man[1,2] ; Kong, Guo-Qiang[2] ; Qi, Hong[2] ; Cui, Juan[2] ; Zhang, Lian-Qun[1] ; Yang, Jie-Zhi[2] ; Li, Ji-Lin[6] ; Li, Xing-Chuan[2] ; Ren, Jing-Li[2] ; Liu, Zhi-Cai[7] ; Gao, Wen-Jun[8] ; Yuan, Ling[2,9] ; Wei, Wu[10,11] ; Zhang, Yan-Rui[12] ; Wang, Wei-Peng[2,4] ; Sheyhidin, Ilyar[13,14] ; Li, Feng[15] ; Chen, Bao-Ping[16] ; Ren, Shu-Wei[17] ; Liu, Bin[18] ; Li, Dan[1,2] ; Ku, Jian-Wei[19] ; Fan, Zong-Min[2] ; Zhou, Sheng-Li[1] ; Guo, Zhi-Gang[1] ; Zhao, Xue-Ke[1] ; Liu, Na[1] ; Ai, Yong-Hong[1] ; Shen, Fang-Fang[1] ; Cui, Wen-Yan[1] ; Song, Shuang[2] ; Guo, Tao[2] ; Huang, Jing[2] ; Yuan, Chao[2] ; Huang, Jia[2] ; Wu, Yue[2] ; Yue, Wen-Bin[20] ; Feng, Chang-Wei[2] ; Li, Hong-Lei[2] ; Wang, Yan[2] ; Tian, Jin-Ya[2] ; Lu, Yue[2] ; Yuan, Yi[1] ; Zhu, Wen-Liang[2] ; Liu, Min[2] ; Fu, Wen-Jing[2] ; Yang, Xia[2] ; Wang, Han-Jing[2] ; Han, Suo-Li[2] ; Chen, Jie[2] ; Han, Min[21] ; Wang, Hai-Yan[1] ; Zhang, Peng[1] ; Li, Xiu-Min[1] ; Dong, Jin-Cheng[2] ; Xing, Guo-Lan[2] ; Wang, Ran[2] ; Guo, Ming[2] ; Chang, Zhi-Wei[2] ; Liu, Hai-Lin[1] ; Guo, Li[2] ; Yuan, Zhi-Qing[1] ; Liu, Hai[22] ; Lu, Qin[2] ; Yang, Liu-Qin[23] ; Zhu, Fu-Guo[21] ; Yang, Xiu-Feng[24] ; Feng, Xiao-Shan[25] ; Wang, Zhou[26] ; Li, Yin[9] ; Gao, She-Gan[25] ; Qige, Qirenwang[27] ; Bai, Long-Tang[27] ; Yang, Wen-Jun[28] ; Lei, Guang-Yan[29] ; Shen, Zhong-Ying[30,31] ; Chen, Long-Qi[32] ; Li, En-Min[30,31] ; Xu, Li-Yan[30,31] ; Wu, Zhi-Yong[30,31] ; Cao, Wei-Ke[33] ; Wang, Jian-Po[2,3] ; Bao, Zhi-Qin[4] ; Chen, Ji-Li[4] ; Ding, Guang-Cheng[2] ; Zhuang, Xiang[2] ; Zhou, Ying-Fa[2] ; Zheng, Hou-Feng[5] ; Zhang, Zheng[5] ; Zuo, Xian-Bo[5] ; Dong, Zi-Ming[2] ; Fan, Dong-Mei[2] ; He, Xin[2] ; Wang, Jin[2] ; Zhou, Qi[2] ; Zhang, Qin-Xian[2] ; Jiao, Xin-Ying[6] ; Lian, Shi-Yong[7] ; Ji, Ai-Fang[10,11] ; Lu, Xiao-Mei[13,14] ; Wang, Jin-Sheng[10,11] ; Chang, Fu-Bao[8] ; Lu, Chang-Dong[3] ; Chen, Zhi-Guo[1] ; Miao, Jian-Jun[4] ; Fan, Zeng-Lin[4] ; Lin, Ruo-Bai[34] ; Liu, Tai-Jiang[35] ; Wei, Jin-Chang[6] ; Kong, Qing-Peng[36] ; Lan, Yu[37] ; Fan, Yu-Jing[37] ; Gao, Fu-Sheng[18] ; Wang, Tian-Yun[1] ; Xie, Dong[38] ; Chen, Shu-Qing[39] ; Yang, Wan-Cai[1] ; Hong, Jun-Yan[39] ; Wang, Liang[1] ; Qiu, Song-Liang[2] ; Cai, Zhi-Ming[40] ; Zhang, Xue-Jun[5] ;
机构： [1]Xinxiang Med Univ, Canc Res Ctr, Xinxiang, Henan, Peoples R China [2]Zhengzhou Univ, Henan Key Lab Esophageal Canc Res, Dept Basic Oncol & Pathol, Coll Med,Affiliated Hosp 1& 2, Zhengzhou, Henan, Peoples R China [3]Anyang Tumor Hosp, Dept Thorac Surg & Tumor Prevent Treatment, Anyang, Henan, Peoples R China [4]Cixian Hosp, Dept Pathol & Thorac Surg, Ctr Hlth Screening & Endoscopy, Cixian, Hebei, Peoples R China [5]Anhui Med Univ, Minist Educ, Key Lab Dermatol, Hefei, Anhui, Peoples R China [6]Linzhou Esophageal Canc Hosp, Dept Pathol & Thorac Surg, Linzhou, Henan, Peoples R China [7]Tumor Hosp Linzhou, Dept Thorac Surg, Linzhou, Henan, Peoples R China [8]Peoples Hosp & Chinese Med Hosp Linzhou, Dept Thorac Surg, Linzhou, Henan, Peoples R China [9]Canc Hosp Henan Prov, Dept Thorac Surg & Radiotherapy, Zhengzhou, Henan, Peoples R China [10]Changzhi Med Univ, Inst Hematol Dis, Changzhi, Shanxi, Peoples R China [11]Changzhi Med Univ, Dept Pathol, Changzhi, Shanxi, Peoples R China [12]Henan Prov Peoples Hosp, Dept Gastroenterol, Zhengzhou, Henan, Peoples R China [13]Xinjiang Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Urumqi, Xinjiang, Peoples R China [14]Xinjiang Med Univ, Affiliated Hosp 1, Med Res Ctr, Urumqi, Xinjiang, Peoples R China [15]Shihezi Univ, Sch Med, Dept Pathol, Shihezi, Xinjiang, Peoples R China [16]Henan Univ, Huaihe Hosp, Dept Nephrol, Kaifeng, Henan, Peoples R China [17]Xinyang Cent Hosp, Dept Oncol, Xinyang, Henan, Peoples R China [18]Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing, Peoples R China [19]Nanyang Med Coll, Affiliated Hosp 1, Dept Oncol, Nanyang, Henan, Peoples R China [20]Peoples Hosp Puyang, Dept Oncol, Puyang, Henan, Peoples R China [21]First Peoples Hosp Shangqiu, Dept Gastroenterol & Thorac Surg, Shangqiu, Henan, Peoples R China [22]Third Peoples Hosp Yunnan Prov, Dept Gastroenterol, Kunming, Yunnan, Peoples R China [23]Cent Hosp Xinxiang, Dept Radiotherapy, Xinxiang, Henan, Peoples R China [24]Hebi Dahejian Hosp, Dept Surg, Hebi, Henan, Peoples R China [25]Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Oncol, Luoyang, Henan, Peoples R China [26]Shandong Univ, Dept Thorac Surg, Prov Hosp, Jinan 250100, Shandong, Peoples R China [27]Inner Mongolia Med Coll, Affiliated Hosp, Dept Internal Mongolia Med, Hohhot, Inner Mongolia, Peoples R China [28]Ningxia Med Univ, Dept Biotechnol, Ningxia, Peoples R China [29]Tumor Hosp Shaanxi Prov, Dept Thorac Surg, Xian, Shaanxi, Peoples R China [30]Shantou Univ, Coll Med, Dept Oncol Pathol, Shantou, Guangdong, Peoples R China [31]Shantou Univ, Coll Med, Dept Biochem & Mol Biol, Shantou, Guangdong, Peoples R China [32]Sichuan Univ, W China Hosp, Dept Thorac & Cardiovasc Surg, Chengdu 610064, Sichuan, Peoples R China [33]Nanjing Med Univ, Huaian Hosp 1, Cent Lab, Huaian, Jiangsu, Peoples R China [34]Fujian Med Univ, Dept Thorac Surg, Union Hosp, Fuzhou, Fujian, Peoples R China [35]Red Cross Hosp Huojia, Dept Surg, Xinxiang, Henan, Peoples R China [36]Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resource & Evolut, Kunming, Yunnan, Peoples R China [37]Peking Univ, Med Coll 4, Beijing Jishuitan Hosp, Dept Gastroenterol, Beijing 100871, Peoples R China [38]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China [39]Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310003, Zhejiang, Peoples R China [40]Peking Univ, Shenzhen Hosp, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen, Guangdong, Peoples R China
出处：
DOI： 10.1038/ng.648
ISSN：

摘要：
We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P-Han combined (for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; PUygur-Kazakh for ESCC = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P-Han combined (for ESCC) = 1.21 x 10(-11), OR = 0.86; PUygur-Kazakh for ESCC = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P-Han for GCA = 1.74 x 10(-39), OR = 1.55 and C20orf54, P-Han for GCA = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

基金：
Xinxiang Medical University [2009-5]; National Natural Science FoundationsNational Natural Science Foundation of China (NSFC) [30670956, 30971133]; 863 HighTech Key ProjectsNational High Technology Research and Development Program of China [2006AA02A403, 2007AA02Z161]; China Key Program on Basic Research [2007CB516812]; Science and Technology Department of Henan Province [2009-8]; Health Department of Henan Province [2009-10]; Education Department of Henan Province [2008-7]; Anhui Provincial Special Scientific Program [2007-7]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类 | 1 区 生物
小类 | 1 区 遗传学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 遗传学
JCR分区：
出版当年[2008]版：
Q1 GENETICS & HEREDITY
最新[2023]版：
Q1 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2008版] 出版当年五年平均 出版前一年[2007版] 出版后一年[2009版]

第一作者：
第一作者机构： [1]Xinxiang Med Univ, Canc Res Ctr, Xinxiang, Henan, Peoples R China [2]Zhengzhou Univ, Henan Key Lab Esophageal Canc Res, Dept Basic Oncol & Pathol, Coll Med,Affiliated Hosp 1& 2, Zhengzhou, Henan, Peoples R China
通讯作者：
通讯机构： [1]Xinxiang Med Univ, Canc Res Ctr, Xinxiang, Henan, Peoples R China [2]Zhengzhou Univ, Henan Key Lab Esophageal Canc Res, Dept Basic Oncol & Pathol, Coll Med,Affiliated Hosp 1& 2, Zhengzhou, Henan, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Li-Dong,Zhou Fu-You,Li Xue-Min,et al.Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54[J].NATURE GENETICS.2010,42(9):759-U46.doi:10.1038/ng.648.
APA：
Wang, Li-Dong,Zhou, Fu-You,Li, Xue-Min,Sun, Liang-Dan,Song, Xin...&Zhang, Xue-Jun.(2010).Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.NATURE GENETICS,42,(9)
MLA：
Wang, Li-Dong,et al."Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54".NATURE GENETICS 42..9(2010):759-U46

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