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Polysialylated Neural Cell Adhesion Molecule Supports Regeneration of Neurons in the Nucleus Ambiguus After Unilateral Recurrent Laryngeal Nerve Avulsion in Adult Rats

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机构： [1]Department of Otorhinolaryngology-Head Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China [2]Department of Otorhinolaryngology- Head Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

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关键词： Recurrent laryngeal nerve Avulsion Nucleus ambiguus Repair Polysialic acid neural cell adhesion molecule

摘要：

Objectives. A correlation appears to exist between the expression of the polysialic acid neural cell adhesion molecule (PSA-NCAM) and repair in central nervous system (CNS) diseases. However, the expression of PSA-NCAM in the CNS after peripheral nerve injury remains unclear. This study aimed to evaluate the expression of PSA-NCAM in the ipsilateral nucleus ambiguus (NA) after unilateral recurrent laryngeal nerve (RLN) avulsion. Materials and Methods. The left RLN of adult Sprague Dawley rats were avulsed. The expression of PSANCAM, PSA-NCAM/NeuN, and PSA-NCAM/Tuj1 in the brain stem was investigated using immunohistochemistry. The results were subjected to one-way analysis of variance followed by the Tukey post hoc test for statistical analyses. Results. PSA-NCAM-positive and PSA-NCAM/NeuN and PSA-NCAM/Tuj1 double-labeled positive cells were observed 7 days post injury in the ipsilateral NA. PSA-NCAM/NeuN and PSA-NCAM/Tuj1 double-labeled cells were observed at 21 and 7 days post injury, respectively. PSA-NCAM/NeuN double-labeled cells were also found in the contralateral NA. Conclusions. After unilateral avulsion of the RLN, the expression of PSA-NCAM in the ipsilateral NA was correlated with the proliferation and the differentiation of neural cells. PSA-NCAM expression may be used as a predictor of the initiation of repair in neural cells.

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最新[2025]版：

大类 | 4 区医学

小类 | 4 区听力学与言语病理学 4 区耳鼻喉科学

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出版当年[2017]版：

无

最新[2023]版：

Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Q1 OTORHINOLARYNGOLOGY

影响因子： 2.5 最新[2023版] 2.2 最新五年平均 0 出版当年[2017版] 0 出版当年五年平均 1.381 出版前一年[2016版] 1.453 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Otorhinolaryngology-Head Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China [2]Department of Otorhinolaryngology- Head Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

通讯作者：

通讯机构： [1]Department of Otorhinolaryngology-Head Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China [*1]Beijing Tongren Hospital, Capital Medical University, 1Dongjiaominxiang Dongcheng District, Beijing 100730, China

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