机构：[1]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing 100730, China.临床科室内分泌科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.首都医科大学附属北京友谊医院[3]Department of Mathematics, School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
BackgroundThe relationship between vitamin D levels and peripheral arterial disease (PAD) remains unclear. We assessed the association of serum 25-hydroxyvitamin D (25(OH)D) levels with the prevalence of PAD in patients with type 2 diabetes mellitus(T2DM).MethodsA total of 1018 T2DM patients participated in this cross-sectional study. Serum 25(OH)D levels were measured and risk factors of PAD were recorded. PAD was diagnosed as an ankle-brachial index (ABI)<0.9.ResultsThe mean age of the diabetic patients was 58.5911.34years. Of all the patients, only 20.1% had a 25(OH)D level20ng/mL. Compared to patients without PAD, serum 25(OH)D levels were significantly lower in those with PAD (14.81 +/- 8.43 vs. 11.55 +/- 5.65ng/mL, P<0.001). The overall prevalence of PAD was 7.7%. From the highest level ( 20ng/mL) to the lowest level (<10ng/mL) of serum 25(OH)D, the prevalence of PAD was 2.8, 7.5 and 10.7% respectively. After adjustment for age, sex, body mass index (BMI), smoking status and season, compared to patients with serum 25(OH)D levels 20ng/mL, the odds ratios of PAD in patients with a level of 10 to <20ng/mL and<10ng/mL was 3.587(95% CI: 1.314-9.790) and 5.540(95% CI: 2.004-15.320), respectively. When further considering the influence of coronary heart disease (CHD), hypertension and cerebral infarction, the ratios changed to 3.824(95% CI: 1.378-10.615) and 5.729(95% CI: 2.028-16.187), respectively. And after further adjustment for the duration of diabetes, glycated hemoglobin (HbA1c) and glomerular filtration rate (GFR), the ratios changed to 3.489(95% CI: 1.100-11.062) and 3.872(95% CI: 1.168-12.841), respectively.Conclusions Reduced serum vitamin D levels were associated with an increased risk of PAD in T2DM patients. Randomized interventive clinical studies are required to verify the effects of vitamin D supplementation on PAD.
基金：
A priming scientific research foundation for the junior researcher in Beijing
Tongren Hospital, Capital Medical University (TRYY-KYJJ-2016-057), awarded
to Jing Yuan, supported this research in the collection and analysis of the
data.
第一作者机构：[1]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing 100730, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Jing Yuan,Pu Jia,Lin Hua,et al.Vitamin D deficiency is associated with risk of developing peripheral arterial disease in type 2 diabetic patients[J].BMC CARDIOVASCULAR DISORDERS.2019,19:doi:10.1186/s12872-019-1125-0.
APA：
Jing Yuan,Pu Jia,Lin Hua,Zhong Xin&Jin-Kui Yang.(2019).Vitamin D deficiency is associated with risk of developing peripheral arterial disease in type 2 diabetic patients.BMC CARDIOVASCULAR DISORDERS,19,
MLA：
Jing Yuan,et al."Vitamin D deficiency is associated with risk of developing peripheral arterial disease in type 2 diabetic patients".BMC CARDIOVASCULAR DISORDERS 19.(2019)
