机构：[1]Institute for Biomedical Engineering and College of Information Engineering, China Jiliang University, Hangzhou, China[2]Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院[3]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China医技科室放射科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院
During the past several years, the rapid development of neuroimaging techniques has contributed greatly in the noninvasive imaging studies of tinnitus. The aim of the present study was to explore the brain anatomical alterations in patients with right-sided unilateral pulsatile tinnitus (PT) in the early stage of PT symptom using voxel-based morphometry (VBM) analysis. Twenty-four patients with right-sided pulsatile tinnitus and 24 age-and gender-matched normal controls were recruited to this study. Structural image data preprocessing was performed using VBM8 toolbox. Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Two-sample t-test and Pearson's correlation analysis were used in statistical analysis. Patients with unilateral pulsatile tinnitus had significantly increased gray matter (GM) volume in bilateral superior temporal gyrus compared with the normal controls. However, the left cerebellum posterior lobe, left frontal superior orbital lobe (gyrus rectus), right middle occipital gyrus (MOG), and bilateral putamen showed significantly decreased brain volumes. This was the first study which demonstrated the features of neuroanatomical changes in patients with unilateral PT during their early stages of the symptom.
基金：
This work was supported by Grant nos. 81371546 and
61527807 from the National Natural Science Foundation of
China, Grant no. SML20150101 from the Beijing Municipal
Administration of Hospitals’ Mission Plan, no. [2015] 160
from Beijing Scholars Program, Grant nos. 7172064 and
7182044 from Beijing Natural Science Foundation and Beijing
Municipal Administration of Hospitals’ Cultivation plan
(Han Lv), and seed Project no. YYZZ2017B01 (Han Lv) from
Beijing Friendship Hospital and Capital Medical University.
第一作者机构：[1]Institute for Biomedical Engineering and College of Information Engineering, China Jiliang University, Hangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Institute for Biomedical Engineering and College of Information Engineering, China Jiliang University, Hangzhou, China[2]Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Yawen Liu,Han Lv,Pengfei Zhao,et al.Neuroanatomical Alterations in Patients with Early Stage of Unilateral Pulsatile Tinnitus: A Voxel-Based Morphometry Study[J].NEURAL PLASTICITY.2018,2018:doi:10.1155/2018/4756471.
APA：
Yawen Liu,Han Lv,Pengfei Zhao,Zhaohui Liu,Wenjing Chen...&Jian-Ming Zhu.(2018).Neuroanatomical Alterations in Patients with Early Stage of Unilateral Pulsatile Tinnitus: A Voxel-Based Morphometry Study.NEURAL PLASTICITY,2018,
MLA：
Yawen Liu,et al."Neuroanatomical Alterations in Patients with Early Stage of Unilateral Pulsatile Tinnitus: A Voxel-Based Morphometry Study".NEURAL PLASTICITY 2018.(2018)
