机构：[1]Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States[2]Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States[3]Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院[4]Eye Research Center and Eye Department, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran[5]Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, South Korea[6]Blanton Eye Institute & Houston Methodist Hospital, Houston, Texas, United States[7]Optos PLC, Dunfermline, United Kingdom.
PURPOSE. The purpose of this study was to compare the use of central and montaged ultrawide-field fluorescein angiography (UWFFA) images for calculating the area of nonperfusion (NP) and ischemic index (ISI) in patients with retinal vein occlusion (RVO) and macular edema (ME) and to correlate these measurements with best-corrected visual acuity (BCVA) and central macular thickness (CMT). METHODS. Thirty eyes of 30 RVO patients with recurrent ME were enrolled. Baseline UWFA images were sent to the Doheny Image Reading Center for quantitative analysis by certified graders. The association between ISI from the various zones and BCVA and CMT was examined by Spearman rank correlation and compared. Generalized linear models (GLMs) were used to analyze associations between BCVA and disease status. RESULTS. The NP area and ISI for central and montaged images were not significantly different for any retinal zone. A modest but statistically significant negative linear correlation was observed between BCVA and ISI, ranging from r = -0.3825 in the perimacular area (PMA) to r = 0.584 in the far peripheral area (FPA). On GLM analysis, both PMA (beta = -1.059; 95% confidence interval: -1.74 to -0.378) and FPA (beta = -0.505; 95% confidence interval: -0.988 to -0.021) were significant independent predictors of BCVA. We found no correlation between ISI from the various zones and CMT in this cohort. CONCLUSIONS. Montaging of UWFFA images may not be required to adequately quantify and represent areas of NP in eyes with RVO. NP in both the PMA and peripheral retina appear relevant to visual function, highlighting the importance of evaluating the retinal periphery in these individuals.
基金：
Supported by a research grant from Genentech, Inc, South San
Francisco, California, United States.
第一作者机构：[1]Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States[2]Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States[3]Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States[2]Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States[*1]Doheny Eye Institute, PO Box 86228, Los Angeles, CA 90086, USA
推荐引用方式(GB/T 7714)：
Kang Wang,Khalil Ghasemi Falavarjani,Muneeswar G. Nittala,et al.Ultra-Wide-Field Fluorescein Angiography-Guided Normalization of Ischemic Index Calculation in Eyes With Retinal Vein Occlusion[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2018,59(8):3278-3285.doi:10.1167/iovs.18-23796.
APA：
Kang Wang,Khalil Ghasemi Falavarjani,Muneeswar G. Nittala,Min Sagong,Charles C.Wykoff...&SriniVas R. Sadda.(2018).Ultra-Wide-Field Fluorescein Angiography-Guided Normalization of Ischemic Index Calculation in Eyes With Retinal Vein Occlusion.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,59,(8)
MLA：
Kang Wang,et al."Ultra-Wide-Field Fluorescein Angiography-Guided Normalization of Ischemic Index Calculation in Eyes With Retinal Vein Occlusion".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 59..8(2018):3278-3285
医学