机构：[1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China[2]Rehabilitation Administration Department, National Institute of Hospital Administration, Chinese National Health and FamilyPlanning Commission, Beijing, China[3]Translational Research for Equitable Eye Care, Centre for Public Health, Royal Victoria Hospital, Queen’s University Belfast, Belfast,United Kingdom[4]Orbis International, New York, New York, United States[5]Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China[6]Centre for Eye Research Australia, Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Australia
PURPOSE. To investigate the prevalence and determinants of diabetic retinopathy (DR) among older adults in rural Southern China. METHODS. Using random cluster sampling, persons aged 50 years or older were randomly selected in rural Yangxi County, Guangdong Province, China. All participants underwent a standardized interview, fundus photography, and point of service glycosylated hemoglobin A1c (HbA1c) testing. Diabetes mellitus (DM) was diagnosed based on confirmed medical history or HbA1c >= 6.5%. Fundus photographs were graded for DR and diabetic macular edema (DME) based on the United Kingdom National Diabetic Eye Screening Program guidelines. Prevalence of and risk factors for DR and vision-threatening diabetic retinopathy (VTDR) were evaluated. RESULTS. Among 5825 subjects who participated (90.7% response rate) in the Yangxi Eye Study, 562 (9.6%) were diagnosed with DM, including 79 (14.1%) known and 483 new (85.9%) cases. Among DM cases, 476 (84.7%) had gradable fundus photos. The prevalence of any DR and VTDR were 8.19% (95% confidence interval [CI] 5.9-11.0) and 5.25% (95% CI 3.43-7.66), respectively. These figures were 23.9% and 12.7% for known and 5.43% and 3.95% for new DM cases. Risk factors for any DR were higher HbA1c level (OR [odds ratio] per unit 1.34, P < 0.001), longer duration of DM (OR per year = 2.29, P < 0.001) and having previously undergone cataract surgery (OR 4.11, P < 0.030). CONCLUSIONS. Our study found a lower prevalence of DR among adults 50 years and older than in previously reports. Perhaps this difference can be explained by the short duration of most cases.
基金：
National Institute of Hospital Administration of the Chinese National Health and Family Planning Commission under ORBIS International North Asia (Beijing, China) [1541]; National Institute of Hospital Administration; Chinese National Health and Family Planning Commission; ORBIS International; Science and Technology Planning Project of Guangdong Province [2013B20400003]; University of Melbourne Research Accelerator Program; CERA Foundation; Victorian State Government; Ulverscroft Foundation (UK); Fundamental Research Funds of the State Key Laboratory in Ophthalmology
第一作者机构：[1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
通讯作者：
通讯机构：[1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China[5]Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China[6]Centre for Eye Research Australia, Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Australia[*1]Zhongshan Ophthalmic Center, #54 Xianlie South Road, Yuexiu District, Guangzhou 510060, People’s Republic of China[*2]Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, #1 Dongjiaomin Street, Dongcheng District, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Jin Guangming,Xiao Wei,Ding Xiaohu,et al.Prevalence of and Risk Factors for Diabetic Retinopathy in a Rural Chinese Population: The Yangxi Eye Study[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2018,59(12):5067-5073.doi:10.1167/iovs.18-24280.
APA：
Jin, Guangming,Xiao, Wei,Ding, Xiaohu,Xu, Xiao,An, Lei...&He, Mingguang.(2018).Prevalence of and Risk Factors for Diabetic Retinopathy in a Rural Chinese Population: The Yangxi Eye Study.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,59,(12)
MLA：
Jin, Guangming,et al."Prevalence of and Risk Factors for Diabetic Retinopathy in a Rural Chinese Population: The Yangxi Eye Study".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 59..12(2018):5067-5073
医学