机构：[1]College of Electronic Information and Control Engineering, Beijing University of Technology, Beijing 100124, China[2]State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China[3]Beijing Key Laboratory of Computational Intelligence and Intelligent System, Beijing 100124, China[4]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China医技科室放射科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[5]Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China首都医科大学附属北京友谊医院
Previous neuroimaging studies suggested structural or functional brain reorganizations occurred in prelingually deaf subjects. However, little is known about the reorganizations of brain network architectures in prelingually deaf adolescents. The present study aims to investigate alterations of whole-brain functional network using resting-state fMRI and graph theory analysis. We recruited 16 prelingually deaf adolescents (10 similar to 18 years) and 16 normal controls matched in age and gender. Brain networks were constructed from mean time courses of 90 regions. Widely distributed network was observed in deaf subjects, with increased connectivity between the limbic system and regions involved in visual and language processing, suggesting reinforcement of the processing for the visual and verbal information in deaf adolescents. Decreased connectivity was detected between the visual regions and language regions possibly due to inferior reading or speaking skills in deaf subjects. Using graph theory analysis, we demonstrated small-worldness property did not change in prelingually deaf adolescents relative to normal controls. However, compared with healthy adolescents, eight regions involved in visual, language, and auditory processing were identified as hubs only present in prelingually deaf adolescents. These findings revealed reorganization of brain functional networks occurred in prelingually deaf adolescents to adapt to deficient auditory input.
基金：
863 Project (2013AA013803), the
National Natural Science Foundation of China (NSFC) (no.
81271557, no. 61271151, and no. 61228103), Youth Innovation Promotion Association CAS, the Beijing Postdoctoral
Research Foundation (no. 2014ZZ-8), the Project Funded by
China Postdoctoral Science Foundation (no. 2015M570911),
and the Basic Research Foundation Project of Beijing University of Technology
第一作者机构：[1]College of Electronic Information and Control Engineering, Beijing University of Technology, Beijing 100124, China[2]State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China[3]Beijing Key Laboratory of Computational Intelligence and Intelligent System, Beijing 100124, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Wenjing,Li Jianhong,Wang Jieqiong,et al.Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents[J].NEURAL PLASTICITY.2016,2016:doi:10.1155/2016/9849087.
APA：
Li, Wenjing,Li, Jianhong,Wang, Jieqiong,Zhou, Peng,Wang, Zhenchang...&He, Huiguang.(2016).Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents.NEURAL PLASTICITY,2016,
MLA：
Li, Wenjing,et al."Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents".NEURAL PLASTICITY 2016.(2016)
