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Aberrant Activation of the Intrarenal Renin-Angiotensin System in the Developing Kidneys of Type 2 Diabetic Rats

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Fan, Y. -Y.[1,2,*1] * ; Kobori, H.[2] ; Nakano, D.[2] ; Hitomi, H.[2] ; Mori, H.[3] ; Masaki, T.[3] ; Sun, Y. -X.[4] ; Zhi, N.[1] ; Zhang, L.[5] ; Huang, W.[6] ; Zhu, B.[7] ; Li, P.[7] ; Nishiyama, A.[2] ;
机构： [1]Department of Traditional Chinese Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, P. R. China [2]Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan [3]Gastroenterology, Kagawa University Medical School, Kagawa, Japan [4]Department of Rehabilitation, The First Hospital of Chinese Medicine University, Shenyang, P. R. China [5]Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, P. R. China [6]Nephrology, Beijing Tongren Hospital, Capital Medical University, Beijing, P. R. China [7]Department of Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, P. R. China
出处：
DOI： 10.1055/s-0032-1331256
ISSN：

关键词： angiotensin II developing kidney diabetes angiotensinogen

摘要：
We have previously reported that intrarenal angiotensin II (Ang II) levels are increased long before diabetes becomes apparent in obese Otsuka-Long-Evans-Tokushima-Fatty (OLETF) rats, a model of type 2 diabetes. In this study, we examined the changes in intrarenal renin-angiotensin system (RAS) activity in the developing kidneys of OLETF rats. Ang II contents and mRNA levels of RAS components were measured in male OLETF and control Long-Evans Tokushima (LETO) rats at postnatal days (PND) 1, 5, and 15, and at 4-30 weeks of age. In both LETO and OLETF rats, kidney Ang II levels peaked at PND 1, then decreased during the pre- and post-weaning periods. However, Ang II levels and gene expression of RAS components, including angiotensinogen (AGT), renin, and angiotensin-converting enzyme (ACE), were not significantly different between LETO and OLETF rats. Intrarenal Ang II contents further decreased during puberty (from 7 to 11 weeks of age) in LETO rats, bur not in OLETF rats. At 11 weeks of age, kidney Ang II levels, urinary AGT excretion, and mRNA levels of AGT and renin were higher in OLETF rats than in LETO rats, while blood glucose levels were not significantly different between these groups of rats. These data indicate that continued intrarenal expression of Ang II during pubescence contributes to the increases in intrarenal Ang II levels in prediabetic OLETF rats, and is associated with increased intrarenal AGT and renin expression. Inappropriate activation of the intrarenal RAS in the prediabetic stage may facilitate the onset and development of diabetic nephropathy in later life.

基金：
We are grateful to the Ministry of Education, Culture, Sports, Science and Technology of Japan (20590253 to Akira Nishiyama) and Nation Natural Science Foundation of China/81141040 to Yu-Yan Fan for supporting our research, and Otsuka Pharmaceutical Co. Ltd. (Tokushima, Japan) for supplying OLETF and LETO rats.
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类 | 3 区 医学
小类 | 4 区 内分泌学与代谢
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 内分泌学与代谢
JCR分区：
出版当年[2011]版：
Q3 ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q3 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者：
第一作者机构： [1]Department of Traditional Chinese Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, P. R. China [2]Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan [*1]Department of Traditional, Chinese Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, No.1, Dong Jiao Min Xiang Street, Dong Cheng District, Beijing 100730, P. R. China
通讯作者：
通讯机构： [1]Department of Traditional Chinese Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, P. R. China [2]Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan [*1]Department of Traditional, Chinese Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, No.1, Dong Jiao Min Xiang Street, Dong Cheng District, Beijing 100730, P. R. China
推荐引用方式(GB/T 7714)：
Fan Y. -Y.,Kobori H.,Nakano D.,et al.Aberrant Activation of the Intrarenal Renin-Angiotensin System in the Developing Kidneys of Type 2 Diabetic Rats[J].HORMONE AND METABOLIC RESEARCH.2013,45(5):338-343.doi:10.1055/s-0032-1331256.
APA：
Fan, Y. -Y.,Kobori, H.,Nakano, D.,Hitomi, H.,Mori, H....&Nishiyama, A..(2013).Aberrant Activation of the Intrarenal Renin-Angiotensin System in the Developing Kidneys of Type 2 Diabetic Rats.HORMONE AND METABOLIC RESEARCH,45,(5)
MLA：
Fan, Y. -Y.,et al."Aberrant Activation of the Intrarenal Renin-Angiotensin System in the Developing Kidneys of Type 2 Diabetic Rats".HORMONE AND METABOLIC RESEARCH 45..5(2013):338-343

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