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Sensitivity of MUC5AC to topical corticosteroid is negatively associated with interleukin-17A in patients with allergic rhinitis

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机构： [1]Allergy and Cancer Center Otorhinolaryngology Hospital, the First Affiliated Hospital of Sun Yat-sen University, and Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, China, [2]Department of Otolaryngology, Chinese PLA General Hospital, Beijing, China, [3]Department of Otolaryngology, Yuebei People’s Hospital, Shaoguan, China, [4]Department of Otolaryngology, the First Affiliated Hospital of Nanchang University, Nanchang, China [5]Department of Otolaryngology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Background: Although Interleukin (IL)-17A has been suggested to play a role in corticosteroid hyporesponsiveness, whether IL-17A is able to affect the sensitivity of MUC5AC to intranasal corticosteroid treatment in patients with allergic rhinitis (AR) is unclear. Methods: Twenty patients with moderate to severe AR were enrolled in this study and the expression of MUC5AC, IL-17A, and glucocorticoid receptor beta (GR beta) was detected using immunochemical staining and quantitative reverse transcription polymerase chain reaction (RT-PCR) before and after treatment with fluticasone propionate (FP) nasal spray for 4 weeks, respectively. In addition, the effects of FP on IL-13- and IL-17A-induced MUC5AC and GR beta were also evaluated in the primarily cultured human nasal epithelial cells (HNECs) in vitro. Results: The increased MUC5AC expression was associated with IL-17A levels in AR, and IL-17A was found to affect the inhibition of MUC5AC by corticosteroid treatment. Both IL-13 and IL-17A significantly promoted MUC5AC mRNA expression in HNECs, and FP treatment was able to significantly inhibit MUC5AC mRNA expression in HNECs induced by IL-13 but not for that induced by IL-17A. Also, IL-17A but not IL-13 promoted GR beta mRNA expression in HNECs, which was not affected by administration of corticosteroid. Conclusion: Our results suggest that the sensitivity of MUC5AC to topical corticosteroid is negatively associated with IL-17A in AR patients. This might help us to gain more insight into the pathophysiology and the pharmacotherapeutic mechanisms on AR treatment. (Am J Rhinol Allergy 26, 359-364, 2012; doi: 10.2500/ajra.2012.26.3795)

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出版当年[2011]版：

大类 | 4 区医学

小类 | 2 区耳鼻喉科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区耳鼻喉科学

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出版当年[2010]版：

Q1 OTORHINOLARYNGOLOGY

最新[2023]版：

Q1 OTORHINOLARYNGOLOGY

影响因子： 2.5 最新[2023版] 2.4 最新五年平均 1.881 出版当年[2010版] 1.801 出版当年五年平均 2.252 出版前一年[2009版] 2.302 出版后一年[2011版]

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第一作者机构： [1]Allergy and Cancer Center Otorhinolaryngology Hospital, the First Affiliated Hospital of Sun Yat-sen University, and Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, China,

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通讯作者：

通讯机构： [1]Allergy and Cancer Center Otorhinolaryngology Hospital, the First Affiliated Hospital of Sun Yat-sen University, and Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, China, [5]Department of Otolaryngology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [*1]Allergy and Cancer Center, Otorhinolaryngology Hospital, the First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou, China 510080 [*2]Department of Otolaryngology, Beijing Tongren Hospital, Capital Medical University, No. 1, Dongjiaomin Lane, Beijing, China100005

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