机构：[1]Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, Beijing, China[2]Department of Nephrology,The First Hospital, ZheJang Medical College, ZheJiang, China[3]Department of Nephrology, ShenZhen Hospital, Peking University,ShenZhen, China北京大学深圳医院深圳市康宁医院深圳医学信息中心[4]Department of Nephrology, The First Hospital, Sun Yat-sen University, GuangZhou, China中山大学附属第一医院[5]Department ofNephrology, The Third Hospital, HeBei Medical University, ShiJia Zhuang, China[6]Department of Nephrology, The Fourth Hospital, HeBeiMedical University, ShiJia Zhuang, China[7]Department of Nephrology, HuaXi Hospital, SiChuan University, ChengDu, China四川大学华西医院[8]Department of Nephrology, The First Hospital, China Medical University, ShenYang, China[9]Department of Nephrology, TongRenHospital, Capital Medical University, Beijing, China[10]Department of Clinical Laboratory, First Hospital, Peking University, Beijing,China
Plasma creatinine may not reflect glomerular filtration rate (GFR) especially in the early stages of chronic kidney disease (CKD). Plasma cystatin C (cysC), however, has the potential to more accurately determine early GFR reduction. We sought to improve the creatinine-based GFR estimation by including cysC measurements. We derived a reference GFR from standard dual plasma sampling Tc-99m-DTPA clearance in a training cohort of 376 randomly selected adult Chinese patients with CKD. We compared reference values to estimated GFR and applied multiple regression models to one equation based solely on cysC, and to another combining plasma creatinine (Pcr) and cysC measurements of the training cohort. The results were validated by testing an additional 191 patients. The difference, precision, and accuracy of the two estimates were compared with the modified Modification of Diet in Renal Disease (MDRD) equation for Chinese patients, and another estimate combining cysC and modified MDRD calculations. The estimated GFR combining Pcr and cysC measurements more accurately matched the reference GFR at all stages of CKD than the other equations, particularly in patients with near-normal kidney function.
基金：
National ‘211 Project’ Peking University Evidence Based Medicine Group
(91000-246156061).
第一作者机构：[1]Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, Beijing, China
通讯作者：
通讯机构：[1]Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, Beijing, China[*1]Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, No. 8 Xishiku Street, Xicheng District, Beijing 100034, PR China
推荐引用方式(GB/T 7714)：
Ma Y-C,Zuo L.,Chen J-H,et al.Improved GFR estimation by combined creatinine and cystatin C measurements[J].KIDNEY INTERNATIONAL.2007,72(12):1535-1542.doi:10.1038/sj.ki.5002566.
APA：
Ma, Y-C,Zuo, L.,Chen, J-H,Luo, Q.,Yu, X-Q...&Wang, H-Y.(2007).Improved GFR estimation by combined creatinine and cystatin C measurements.KIDNEY INTERNATIONAL,72,(12)
MLA：
Ma, Y-C,et al."Improved GFR estimation by combined creatinine and cystatin C measurements".KIDNEY INTERNATIONAL 72..12(2007):1535-1542
医学