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Effects of Aberrant miR-384-5p Expression on Learning and Memory in a Rat Model of Attention Deficit Hyperactivity Disorder(Open Access)

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机构： [1]Department of Child Health Care, Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing, China, [2]Department of Pediatrics, First People’s Hospital of Foshan, Affiliated Foshan Hospital of Sun Yat-sen University, Foshan, China, [3]Jiangsu Key Laboratory of Pediatrics, Institute of Pediatrics, Nanjing Medical University, Nanjing, China, [4]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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关键词： attention deficit hyperactivity disorder cognition dopamine receptor D1 learning and memory microRNA prefrontal cortex

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Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder characterized by inattention, hyperactivity, and impulsivity. It may be accompanied by learning difficulties and working memory deficits. Few studies have examined the role of miRNAs in cognitive dysfunction in ADHD. This study investigated the effects of aberrant miR-384-5p expression on learning and memory in a widely used ADHD rat model. Lentiviral vectors were injected into the lateral ventricles of the rats to increase or decrease miR-384-5p level. To determine whether aberrant miR-384-5p expression affects learning and memory, spontaneous activity and cognitive function were assessed with the open field and Morris water maze tests. In the place navigation experiment of the Morris water maze test, time, and total swimming distance to reach the platform decreased compared to the control group when miR-384-5p was overexpressed, whereas down-regulation of miR-384-5p had the opposite effect. There were no obvious changes in brain tissue morphology following miR-384-5p overexpression or inhibition; however, dopamine (DA) receptor D1 (DRD1) level has decreased and increased, respectively, in the prefrontal cortex (PFC). The luciferase activity of the wild-type DRD1 group has decreased in luciferase reporter assay. Cyclic AMP response element-binding protein (CREB) phosphorylation has increased, and DA transporter (DAT) level has decreased in the PFC of spontaneously hypertensive rats (SHR) by miR-384-5p overexpression. On the other hand, miR-384-5p suppression increased DRD1 and decreased DAT and CREB protein levels relative to control rats. These findings suggest that miR-384-5p may play a critical role in learning and memory impairment in ADHD. © Copyright © 2020 Xu, Ou, Zhang, Tang, Wang, Hong, Guo, Tong, Yang and Chi.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

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出版当年[2018]版：

Q3 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 3.3 最新五年平均 2.635 出版当年[2018版] 3.233 出版当年五年平均 3.508 出版前一年[2017版] 2.889 出版后一年[2019版]

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第一作者机构： [1]Department of Child Health Care, Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing, China,

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通讯机构： [1]Department of Child Health Care, Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing, China, [3]Jiangsu Key Laboratory of Pediatrics, Institute of Pediatrics, Nanjing Medical University, Nanjing, China,

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