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Prevalence and Pattern of Geographic Atrophy in Asia The Asian Eye Epidemiology Consortium

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收录情况： ◇ SCIE

作者：
Rim, Tyler Hyungtaek[1,2] * ; Kawasaki, Ryo[3,4] * ; Tham, Yih-Chung[1,2] ; Kang, Se Woong[5] ; Ruamviboonsuk, Paisan[6] ; Bikbov, Mukharram M.[7] ; Miyake, Masahiro[4,8] ; Hao, Jie[9] ; Fletcher, Astrid[10] ; Sasaki, Mariko[4,11] ; Nangia, Vinay[12] ; Sabanayagam, Charumathi[1,2] ; Yu, Marco[1] ; Fujiwara, Kohta[4,13] ; Thapa, Raba[14] ; Wong, Ian Y.[15] ; Kayama, Takamasa[16] ; Chen, Shih-Jen[17] ; Kuang, Tung-Mei[17] ; Yamashita, Hidetoshi[16] ; Sundaresan, Periasamy[18] ; Chan, Jonathan C.[19] ; van Rens, G. H. M. B.[20] ; Sonoda, Koh-Hei[21] ; Wang, Ya Xing[9] ; Panda-Jonas, Songhomitra[22] ; Harada, Sei[23] ; Kim, Ramasamy[24] ; Ganesan, Suganeswari[25] ; Raman, Rajiv[25] ; Yamashiro, Kenji[8,26] ; Gilmanshin, Timur R.[7] ; Jenchitr, Watanee[27] ; Park, Kyu Hyung[28] ; Cheung, Chui Ming Gemmy[1,2] ; Wong, Tien Yin[1,2] ; Wang, Ningli[9] ; Jonas, Jost B.[29] ; Chakravarthy, Usha[30] ; Cheng, Ching-Yu[1,2,*1] ; Yanagi, Yasuo[1,4,31,*2] ;
机构： [1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. [2]Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore. [3]Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. [4]Ganka Ekigaku Network, Osaka, Japan. [5]Department of Ophthalmology of Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. [6]Department of Ophthalmology, Rajavithi Hospital, Bangkok, Thailand. [7]Ufa Eye Research Institute, Ufa, Russia. [8]Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan. [9]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [10]London School of Hygiene & Tropical Medicine, London, United Kingdom. [11]Department of Ophthalmology, Keio University school of medicine, Tokyo, Japan. [12]Suraj Eye Institute, Nagpur, India. [13]Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. [14]Tilganga Institute of Ophthalmology, Kathmandu, Nepal. [15]University of Hong Kong and Hong Kong Sanatorium and Hospital, Hong Kong. [16]Yamagata University Faculty of Medicine, Yamagata, Japan. [17]Department of Ophthalmology, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan. [18]Department of Molecular Genetics, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India. [19]Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong. [20]Department of Ophthalmology, Amsterdam University Medical Center, Vrije University Amsterdam, Amsterdam, The Netherlands. [21]Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. [22]Augenpraxis Jonas, Heidelberg, Germany. [23]Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan. [24]Department of Ophthalmology, Aravind Eye Hospital, Madurai, Tamil Nadu, India. [25]Medical Research Foundation, Sankara Nethralaya, Chennai, India. [26]Department of Ophthalmology, Otsu Red Cross Hospital, Otsu, Japan. [27]Rangsit Eye Center and Faculty of Optometry, Rangsit University, Bangkok, Thailand. [28]Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea. [29]Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany. [30]Queen’s University of Belfast, Belfast, Northern Ireland. [31]Department of Ophthalmology, Asahikawa Medical University, Hokkaido, Japan.
出处：
DOI： 10.1016/j.ophtha.2020.04.019
ISSN：

摘要：
Purpose: Although there have been many population-based studies of age-related macular degeneration (AMD), only limited information is available in Asia on the epidemiology of geographic atrophy (GA). We aimed to determine the prevalence and patterns of GA through an analysis of multiple studies conducted within the Asian Eye Epidemiology Consortium (AEEC). Design: Cross-sectional meta-analyses. Participants: A total of 97 213 individuals aged 40 years and older. Methods: Data from 22 population-based studies from countries belonging to the AEEC were included. In all studies, AMD was defined on the basis of standardized grading systems. Geographic atrophy was defined as an area of pallor in the fundus with visibility of the underlying choroidal blood vessels and sharply defined borders. Random-effects meta-analysis was performed to estimate overall and age-, gender-, and region-specific pooled prevalence of GA. Main Outcome Measures: Prevalence of GA per 1000 persons. Results: The mean age was 60.8 +/- 10.0 years, and 42 673 (43.9%) were male. Overall, a total of 223 individuals (0.2%) had GA. The pooled overall prevalence of GA was 1.57 per 1000 persons (95% confidence interval [CI], 1.04-2.10), which was 3 times less than that of neovascular AMD of 5.20 per 1000 persons (95% CI, 3.97-6.43). Compared with those aged 50 to 59 years, the prevalence of GA increased from 0.34 per 1000 persons (95% CI, 0.07-0.62) to 2.90 per 1000 persons (95% CI, 1.55-4.25) in those aged >= 70 years. The GA prevalence per 1000 persons was similar between urban (2.22; 95% CI, 1.22-3.23) and rural residents (1.33; 95% CI, 0.70-1.96). Geographic atrophy was more prevalent in South Asia (based on studies from India and Nepal, 3.82 per 1000 persons; 95% CI, 1.72-5.93) compared with East Asia (based on studies from China, Korea, Hong Kong, Taiwan, and Japan, and the Singapore Chinese Eye Study, 0.76 per 1000 persons; 95% CI, 0.31-1.22, P = 0.005). Conclusions: Geographic atrophy is uncommon in Asian populations compared with those of European ancestry. Even within Asia, geographic differences in GA prevalence were seen. The findings of this meta-analysis suggest that better dissection of risk factors in the Asian population for GA may provide insights into the biological pathways that drive these late-stage manifestations, thus suggesting better targets for prevention. (C) 2020 by the American Academy of Ophthalmology

基金：
National Medical Research Council of SingaporeNational Medical Research Council, Singapore [NMRC/OFLCG/004a/2018, NMRC/CIRG/1488/2018, NMRC/CIRG/1417/2015]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
JCR分区：
出版当年[2018]版：
Q1 OPHTHALMOLOGY
最新[2023]版：
Q1 OPHTHALMOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. [2]Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore.
共同第一作者：
通讯作者：
通讯机构： [1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. [2]Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore. [4]Ganka Ekigaku Network, Osaka, Japan. [31]Department of Ophthalmology, Asahikawa Medical University, Hokkaido, Japan. [*1]Singapore Eye Research Institute 20 College Road, The Academia, Level 6, Discovery Tower, Singapore 169856. [*2]Singapore Eye Research Institute, 20 College Road, The Academia, Level 6, Discovery Tower, Singapore 169856.
推荐引用方式(GB/T 7714)：
Rim Tyler Hyungtaek,Kawasaki Ryo,Tham Yih-Chung,et al.Prevalence and Pattern of Geographic Atrophy in Asia The Asian Eye Epidemiology Consortium[J].OPHTHALMOLOGY.2020,127(10):1371-1381.doi:10.1016/j.ophtha.2020.04.019.
APA：
Rim, Tyler Hyungtaek,Kawasaki, Ryo,Tham, Yih-Chung,Kang, Se Woong,Ruamviboonsuk, Paisan...&Yanagi, Yasuo.(2020).Prevalence and Pattern of Geographic Atrophy in Asia The Asian Eye Epidemiology Consortium.OPHTHALMOLOGY,127,(10)
MLA：
Rim, Tyler Hyungtaek,et al."Prevalence and Pattern of Geographic Atrophy in Asia The Asian Eye Epidemiology Consortium".OPHTHALMOLOGY 127..10(2020):1371-1381

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