Marjolin's ulcer is a rare malignancy arising from various forms of scars,mainly an old scar resulted from burn.The second most common origin is malignant degeneration arising from tissue within osteomyelitis fistulae.Not uncommonly,the lesions may arise secondary to ulcers due to venous insufficiency or pressure sores.The pathology of the majority of Marjolin's ulcer is a well-differentiated squamous cell carcinoma.The exact reason for an ulcer which undergoes a malignant transformation is unknown.The pathologic diagnosis is the gold standard.Surgery remains the preferred treatment after diagnosis is reached.Wide surgical excision with margins up to 2-3 cm has been suggested.The necessity of whether lymphatic dissection should be executed,or radiotherapy and chemotherapy following surgery is still in dispute.This article deals with the etiology of Marjolin's ulcer and its pathological grading,diagnosis,treatment,prognosis,and prevention,with a hope to provide some useful clinical information.