Objective: This study aimed to analyze the diagnostic value of miR-30b and miR-30d in endometriosis (EMS) and whether they are risk factors. Methods: Altogether 184 infertile women admitted to Tongren Hospital of Wuhan University from March 2018 to March 2019 were selected. Among them, 99 patients with EMS were selected as the EMS group, and 85 patients with infertility and normal pelvic cavities were selected as the normal group. Serum miR-30b and miR-30d of the two groups were detected, and the possibility of their participation in the diagnosis and risk factors of endometriosis was analyzed. Results: Serum miR-30b and miR-30d were significantly down-regulated in the EMS group. AUC of miR-30b and miR-30d for diagnosis of EMS were 0.855 and 0.862. AUC of combined diagnosis of EMS was 0.949. Serum miR-30b and miR-30d were significantly negatively correlated with AFS stage and dysmenorrhea degree. Age, duration of infertility, dysmenorrhea, EMS family history, serum miR-30b and miR-30d were all risk factors affecting EMS in infertile women. Conclusion: miR-30b and miR-30d can be used as diagnostic indicators of EMS, and they are also risk factors for EMS.
第一作者机构：[1]Wuhan Univ, Wuhan Hosp 3, Tongren Hosp, Dept Obstet & Gynecol, Wuhan, Hubei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]Hubei Univ Med, Taihe Hosp, Dept Obstet & Gynecol, 32 Renmin South Rd, Shiyan, Hubei, Peoples R China[*1]Depart-ment of Obstetrics and Gynecology, Taihe Hospital, Hubei University of Medicine, No. 32, Renmin Sou-th Road, Shiyan, Hubei Province, China.
推荐引用方式(GB/T 7714)：
Wang Huimin,Wei Qiong,Yin Heng,et al.miR-30b and miR-30d are potential diagnostic indicators and risk factors for endometriosis[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2020,13(6):4219-4226.
APA：
Wang, Huimin,Wei, Qiong,Yin, Heng&Xie, Yongjun.(2020).miR-30b and miR-30d are potential diagnostic indicators and risk factors for endometriosis.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,13,(6)
MLA：
Wang, Huimin,et al."miR-30b and miR-30d are potential diagnostic indicators and risk factors for endometriosis".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 13..6(2020):4219-4226
