We studied admission and dynamic demographic, hematological and biochemical co-variates in 1449 hospitalized subjects with coronavirus infectious disease-2019 (COVID-19) in five hospitals in Wuhan, Hubei province, China. We identified two admission co-variates: age (Odds Ratio [OR] = 1.18, 95% Confidence Interval [CI] [1.02, 1.36];P = 0.026) and baseline D-dimer (OR = 3.18 [1.48, 6.82];P = 0.003) correlated with an increased risk of death in persons with COVID-19. We also found dynamic changes in four co-variates, Delta fibrinogen (OR = 6.45 [1.31, 31.69];P = 0.022), Delta platelets (OR = 0.95 [0.90-0.99];P = 0.029), Delta C-reactive protein (CRP) (OR = 1.09 [1.01, 1.18];P = 0.037), and Delta lactate dehydrogenase (LDH) (OR = 1.03 [1.01, 1.06];P = 0.007) correlated with an increased risk of death. The potential risk factors of old age, high baseline D-dimer, and dynamic co-variates of fibrinogen, platelets, CRP, and LDH could help clinicians to identify and treat subjects with poor prognosis.