Background: The prognosis of mucosal melanoma is poor, and the difference in clinical prognosis between patients with and without pigment needs further study. Aim: To analyze data with head and neck mucosal melanoma, and compare the prognosis of patients with and without pigment. Material and methods: The patients of amelanotic melanoma were matched with pigmented type according to age, sex, stage, location of disease, treatment history, tobacco and alcohol history. The Kaplan-Meier and Cox proportional risk regression model was used for analyzation. Results: 46 patients of amelanotic melanoma and 46 of pigmented type were included in this study. The overall survival rate and progression-free survival rate of patients with pigmented melanoma were higher than in patients with amelanotic melanoma (HR = 0.533, p = .035, 95% CI = 0.296-0.957; HR = 0.530, p = .034, 95% CI = 0.294-0.953, respectively), and the risk of distant metastases in patients with amelanotic melanoma was significantly higher than that in patients with pigmented melanoma (HR = 0.474, p = .046, 95% CI = 0.228-0.987). Conclusions and significance: The prognosis and disease-free survival of amelanotic melanoma is worse than for the pigmented type group. More identifying the differences in clinical characteristics will help to further individualized treatment decisions.
第一作者机构:[1]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China[*1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Key Lab Otolaryngol Head & Neck Surg, 1 Dongjiaomin Lane, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714):
Guo Wei,Yin Gaofei,Liu Hongfei,et al.Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck[J].ACTA OTO-LARYNGOLOGICA.2020,140(9):785-788.doi:10.1080/00016489.2020.1763456.
APA:
Guo, Wei,Yin, Gaofei,Liu, Hongfei,Duan, Hanyuan,Huang, Zhigang&Chen, Xiaohong.(2020).Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck.ACTA OTO-LARYNGOLOGICA,140,(9)
MLA:
Guo, Wei,et al."Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck".ACTA OTO-LARYNGOLOGICA 140..9(2020):785-788