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Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck

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机构: [1]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China
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关键词: Head and neck mucosal melanoma pigmented type amelanotic melanoma

摘要:
Background: The prognosis of mucosal melanoma is poor, and the difference in clinical prognosis between patients with and without pigment needs further study. Aim: To analyze data with head and neck mucosal melanoma, and compare the prognosis of patients with and without pigment. Material and methods: The patients of amelanotic melanoma were matched with pigmented type according to age, sex, stage, location of disease, treatment history, tobacco and alcohol history. The Kaplan-Meier and Cox proportional risk regression model was used for analyzation. Results: 46 patients of amelanotic melanoma and 46 of pigmented type were included in this study. The overall survival rate and progression-free survival rate of patients with pigmented melanoma were higher than in patients with amelanotic melanoma (HR = 0.533, p = .035, 95% CI = 0.296-0.957; HR = 0.530, p = .034, 95% CI = 0.294-0.953, respectively), and the risk of distant metastases in patients with amelanotic melanoma was significantly higher than that in patients with pigmented melanoma (HR = 0.474, p = .046, 95% CI = 0.228-0.987). Conclusions and significance: The prognosis and disease-free survival of amelanotic melanoma is worse than for the pigmented type group. More identifying the differences in clinical characteristics will help to further individualized treatment decisions.

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出版当年[2019]版:
大类 | 4 区 医学
小类 | 4 区 耳鼻喉科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 耳鼻喉科学
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出版当年[2018]版:
Q4 OTORHINOLARYNGOLOGY
最新[2023]版:
Q3 OTORHINOLARYNGOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

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第一作者机构: [1]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China
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通讯机构: [1]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China [*1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Key Lab Otolaryngol Head & Neck Surg, 1 Dongjiaomin Lane, Beijing 100730, Peoples R China
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