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Use of Nasal Nitric Oxide in the Diagnosis of Allergic Rhinitis and Nonallergic Rhinitis in Patients with and without Sinus Inflammation

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收录情况： ◇ SCIE

作者：
Liu, Chengyao[1,2] * ; Zheng, Kaili[1,2] * ; Liu, Xiaofang[3] ; Zheng, Ming[1,2] ; Liu, Zhongyan[4] ; Wang, Xiangdong[1,2,4,*1] ; Zhang, Luo[1,2,4,*1] ;
机构： [1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China [2]Capital Med Univ, Beijing Tongren Hosp, Dept Allergy, Beijing, Peoples R China [3]Capital Med Univ, Beijing Tongren Hosp, Dept Resp Med, Beijing, Peoples R China [4]Minist Educ, Beijing Inst Otolaryngol, Key Lab Otorhinolaryngol Head & Neck Surg, Beijing Key Lab Nasal Dis, Beijing, Peoples R China
出处：
DOI： 10.1016/j.jaip.2019.12.017
ISSN：

摘要：
Nasal nitric oxide (nNO) has been evaluated in patients with chronic rhinosinusitis with and without nasal polyps. However, nNO levels in patients with allergic rhinitis (AR) and nonallergic rhinitis (NAR) have shown conflicting results in previous studies.To evaluate the value of nNO in diagnosing AR and NAR and the impact of absence or presence of sinus inflammation (SI).A total of 173 consecutive patients scanned with high-resolution computed tomography (CT) and 46 normal controls (NCs) were included in our study. Patients were evaluated according to their medical history, nasal symptoms, endoscopic examinations, and skin prick test results. On the basis of CT scans (Lund-Mackay score >2), all patients were subgrouped as AR with SI (ARwSI) and AR without SI (ARsSI), or NAR with SI (NARwSI) and NAR without SI (NARsSI). nNO levels were measured with the NIOX, and eosinophils in nasal smears were evaluated simultaneously. Receiver-operating characteristic analysis was performed for differential diagnosis of AR, NAR, and subgroups.Ninety-four patients were diagnosed with AR and 79 patients with NAR. The levels of nNO were significantly higher in patients with AR and in NCs compared with patients with NAR (939 ± 335 in AR and 813 ± 272 in NCs vs 670 ± 188 in NAR; P < .001 for both), and significantly higher in patients with AR compared with NCs (P < .05). On the basis of sinus CT scans, 49% patients with AR (46 of 94) were defined as ARwSI and 51% patients with NAR (40 of 79) were defined as NARwSI. Patients with ARsSI showed the highest nNO levels (1180 ± 289) compared with other subgroups (P < .001), and patients with NARwSI showed the lowest nNO levels (522 ± 120) compared with other subgroups (P < .001). nNO could be used to discriminate AR, NAR, and subgroups with acceptable sensitivity and specificity. Moreover, patients with nasal smear eosinophilia had lower nNO levels than did patients with NAR (P < .05).nNO levels are different between patients with ARwSI/ARsSI and NARwSI/NARsSI, and may be used to discriminate these phenotypes.Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

基金：
National Key R&D Program of China [2016YFC0905200]; program for the Changjiang Scholars and Innovative Research TeamProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT13082]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81630023, 81570894, 81970852]; Beijing Municipal Administration of Hospitals' Mission Plan [SML20150203]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7172054]; Beijing Scientific and Technological Overall Plan [Z171100000117002]; Beijing Bai-QianWan Talent Project [2019A32]; Public Welfare Development and Reform Pilot Project
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 医学
小类 | 1 区 过敏 2 区 免疫学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 过敏 1 区 免疫学
JCR分区：
出版当年[2018]版：
Q1 IMMUNOLOGY Q1 ALLERGY
最新[2023]版：
Q1 ALLERGY Q1 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China [2]Capital Med Univ, Beijing Tongren Hosp, Dept Allergy, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构： [1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China [2]Capital Med Univ, Beijing Tongren Hosp, Dept Allergy, Beijing, Peoples R China [4]Minist Educ, Beijing Inst Otolaryngol, Key Lab Otorhinolaryngol Head & Neck Surg, Beijing Key Lab Nasal Dis, Beijing, Peoples R China [*1]Beijing Inst Otolaryngol, 17 Hougou Hutong, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Chengyao,Zheng Kaili,Liu Xiaofang,et al.Use of Nasal Nitric Oxide in the Diagnosis of Allergic Rhinitis and Nonallergic Rhinitis in Patients with and without Sinus Inflammation[J].JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE.2020,8(5):1574-+.doi:10.1016/j.jaip.2019.12.017.
APA：
Liu, Chengyao,Zheng, Kaili,Liu, Xiaofang,Zheng, Ming,Liu, Zhongyan...&Zhang, Luo.(2020).Use of Nasal Nitric Oxide in the Diagnosis of Allergic Rhinitis and Nonallergic Rhinitis in Patients with and without Sinus Inflammation.JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE,8,(5)
MLA：
Liu, Chengyao,et al."Use of Nasal Nitric Oxide in the Diagnosis of Allergic Rhinitis and Nonallergic Rhinitis in Patients with and without Sinus Inflammation".JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE 8..5(2020):1574-+

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