机构：[1]Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China[2]Tong-ren Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China
Background Type 2 diabetes mellitus (T2DM) is associated with a higher fracture risk. Sex hormones are important for maintaining skeletal health. It is not clear which sex hormone(s) contribute(s) to bone mineral density (BMD) and fracture risk in males with T2DM. This study investigated the relationships of these parameters in males with T2DM. Methods This study involved 482 men with T2DM. BMDs at the lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). The 10-year probability of fractures was assessed using the modified Fracture Risk Algorithm (FRAX) tool. Serum levels of sex hormones were measured. Results Follicle-stimulating hormone (FSH) and estradiol (E2) were associated with BMDs at L2-4 (FSH, beta = -.162, P < .05; E2, beta = .176, P < .001), and E2 was associated with BMD at FN (beta = .137, P < .05) and TH (beta = .140, P < .05). FSH was associated with major osteoporotic fractures (beta = .288, P < .001) and hip fractures (beta = .235, P < .001). Higher FSH was a risk factor for osteoporosis/osteopenia (odds ratios [OR] = 2.92, 95% CI = 1.66-5.14, P < .001), whereas higher E2 was a protective factor (OR = 0.37, 95% CI = 0.22-0.60, P < .001). Patients in the higher tertile of FSH and lower tertile of E2 had an increased risk of osteoporosis/osteopenia (OR = 5.05, 95% CI = 1.37-18.65, P < .05). Conclusions For males with T2DM, FSH and E2 are significantly associated with BMD, osteoporosis/osteopenia, and fracture risk.
基金：
Chinese National Natural Science
Foundation, Grant/Award Numbers:
81370018, 81570796; Shanghai Health and
Family Planning Commission, Grant/
Award Number: 201540166
第一作者机构：[1]Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China
通讯作者：
通讯机构：[1]Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China[*1]Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, 197 Rui-jin Er Road, Shanghai, China.
推荐引用方式(GB/T 7714)：
Jing Yixuan,Wang Xiaofeng,Yu Jingjia,et al.Follicle-stimulating hormone and estradiol are associated with bone mineral density and risk of fractures in men with type 2 diabetes mellitus[J].JOURNAL OF DIABETES.2020,12(6):426-437.doi:10.1111/1753-0407.13011.
APA：
Jing Yixuan,Wang Xiaofeng,Yu Jingjia,Wang Xiaojing,Zhou Yanman...&Zhao Hongyan.(2020).Follicle-stimulating hormone and estradiol are associated with bone mineral density and risk of fractures in men with type 2 diabetes mellitus.JOURNAL OF DIABETES,12,(6)
MLA：
Jing Yixuan,et al."Follicle-stimulating hormone and estradiol are associated with bone mineral density and risk of fractures in men with type 2 diabetes mellitus".JOURNAL OF DIABETES 12..6(2020):426-437
