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USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination.

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机构: [1]Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai, China. [2]Hongqiao Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China. [3]Department of Thoracic Surgery, Lanling People's Hospital, Lanling County, Linyi, China. [4]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry & Molecular Cellular Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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Snail is a prominent epithelial-mesenchymal transition (EMT) transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway. Deubiquitinases prevent Snail degradation by regulating the ubiquitination-mediated hydrolysis process. Our studies demonstrate that a deubiquitinating enzyme (DUB) family member, USP37, can deubiquitinate Snail and prevent degradation of Snail. USP37 is co-localized with Snail in the nucleus. Biologically, upregulated expression of USP37 promotes lung cancer cell migration, while depletion of Snail abolishes the effect of USP37. These data demonstrate that USP37 is a Snail-specific deubiquitinase and also indicate a potential therapeutic target for metastasis.Copyright © 2020 Cai, Li, Wang, Li, Li, Hou, Jia and Liu.

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出版当年[2019]版:
大类 | 2 区 生物
小类 | 3 区 遗传学
最新[2023]版:
大类 | 3 区 生物学
小类 | 3 区 遗传学
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出版当年[2018]版:
Q2 GENETICS & HEREDITY
最新[2023]版:
Q2 GENETICS & HEREDITY

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第一作者机构: [1]Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
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通讯机构: [2]Hongqiao Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China. [4]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry & Molecular Cellular Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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