机构：[1]Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology,Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease,[2]Department of Endoscopy, The Sixth People’s Hospital,Shanghai, China[3]Department of Endoscopy, Huashan Hospital, Shanghai,Shanghai, China[4]Shanghai East Hospital, Tongji University School of Medicine,Shanghai, China[5]Tongren Hospital, Shanghai Jiaotong University, Shanghai, China
Background and Aim Clear visualization of the small bowel is a requirement for satisfactory video capsule endoscopy (VCE). The aim of this study was to identify the optimal dose and timing of polyethylene glycol (PEG) for small bowel preparation before VCE. Methods A total of 410 patients were enrolled in this prospective randomized trial. All patients fasted for 12 h and ingested 320 mg simethicone 30 min before swallowing the capsule. Patients were randomized into five groups: Group A (no PEG), Group B (1-L PEG, 12 h before VCE), Group C (2-L PEG, 12 h before VCE), Group D (1-L PEG, 4 h before VCE), and Group E (2-L PEG, 4 h before VCE). The primary endpoint was small bowel visualization quality (SBVQ), and the secondary endpoints were patient acceptability and diagnosis rate of VCE. Results Excellent SBVQ was achieved in 27 (32.5%) of Group A, 38 (46.3%) of Group B, 40 (48.2%) of Group C, 55 (66.3%) of Group D, and 43 (54.4%) of Group E. The percentage of excellent SBVQ in Group D was significantly more than in Group A (66.3% vs 32.5%, P < 0.001), and diagnostic rate in the distal segment was higher (28.9% vs 10.8%, P = 0.0035). Patient acceptance of 1-L PEG was better than of 2-L PEG (P < 0.005). Conclusion Small bowel cleansing with 1-L PEG given 4 h before VCE was the optimal preparation for visualization of the bowel and patient acceptance (, ID: NCT02486536).
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670505]; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine [DLY201501]; Threeyear action plan for Shen Kang of Shanghai [16CR3113B]; Shanghai Municipal Key Clinical Specialty [shslczdzk05902]
第一作者机构：[1]Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology,Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease,[2]Department of Endoscopy, The Sixth People’s Hospital,Shanghai, China
通讯作者：
通讯机构：[1]Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology,Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease,[*1]Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200127, China.
推荐引用方式(GB/T 7714)：
Wu Shan,Zhong Liang,Zheng Ping,et al.Low-dose and same day use of polyethylene glycol improves image of video capsule endoscopy: A multi-center randomized clinical trial[J].JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY.2020,35(4):634-640.doi:10.1111/jgh.14899.
APA：
Wu, Shan,Zhong, Liang,Zheng, Ping,Wang, Yu-Gang,Ding, Wei-Qun...&Ge, Zhi-Zheng.(2020).Low-dose and same day use of polyethylene glycol improves image of video capsule endoscopy: A multi-center randomized clinical trial.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,35,(4)
MLA：
Wu, Shan,et al."Low-dose and same day use of polyethylene glycol improves image of video capsule endoscopy: A multi-center randomized clinical trial".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 35..4(2020):634-640
