Factors associated with overall survival and relief of dysphagia in advanced esophageal cancer patients after I-125 seed-loaded stent placement: a multicenter retrospective analysis
机构：[1]Center of Interventional Radiology and Vascular Surgery, Department of Radiology,Zhongda Hospital, Medical School, Southeast University, Nanjing[2]Department of Interventional Radiology, First Affiliated Hospital of Soochow University, Suzhou,[3]Department of Digestion, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Southeast University[4]Department of Interventional Radiology, AffiliatedHospital ofXuzhou Medical University, Xuzhou[5]Interventional Center, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[6]Clinical Research Institute, Zhongda Hospital, Medical School, Southeast University, Nanjing
Iodine-125 (I-125) seed-loaded stent placement has served as an effective palliation for malignant esophageal strictures in China. We performed a retrospective study to identify the prognostic factors of this irradiation stent placement in advanced esophageal cancer patients. A total of 201 patients who underwent I-125 seed-loaded stent placement were included in this study from June 2012 to March 2016 at five hospitals in China. The Cox regression models adjusted for stratification factors were used, and a stepwise multivariate analysis was performed to predict the overall survival and relief of dysphagia on the basis of pretreatment clinical characteristics, respectively. Three independent prognostic factors were identified for overall survival: histopathological subtype (squamous cell carcinoma vs. adenocarcinoma, hazard ratio [HR] 1.45, 95% confidence interval [CI95%]: 1.01-2.09, P = 0.046), serum total protein (>= 66 g/L vs. <66 g/L, HR 0.61, CI95%: 0.48-0.59, P = 0.023), and performance status (<2 vs. >= 2, HR 1.57, CI95%: 1.09-2.08, P = 0.013). Four factors were significantly associated with the relief of dysphagia: T stage (T3 vs. T4, P = 0.003), tumor location (superior vs. inferior, P = 0.049), tumor-node-metastasis classification (IV vs. II, P = 0.025), and age (>= 71 years vs. <71 years, P = 0.029). Prognostic factors identified from this analysis can be used to aid clinical decision-making and design future clinical trials.
基金：
This study was funded by National Basic Research
Program of China (973 Program # 2013CB733800,
2013733803), National Natural Science Foundation
of China (81671796), Jiangsu Provincial Special Program
of Medical Science (BL2013029), and Jiangsu
Provincial Medical Talent (ZDRCA2016078).
第一作者机构：[1]Center of Interventional Radiology and Vascular Surgery, Department of Radiology,Zhongda Hospital, Medical School, Southeast University, Nanjing
通讯作者：
通讯机构：[1]Center of Interventional Radiology and Vascular Surgery, Department of Radiology,Zhongda Hospital, Medical School, Southeast University, Nanjing[*1]Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China.
推荐引用方式(GB/T 7714)：
Qin J.,Zhu H-D,Guo J-H,et al.Factors associated with overall survival and relief of dysphagia in advanced esophageal cancer patients after I-125 seed-loaded stent placement: a multicenter retrospective analysis[J].DISEASES OF THE ESOPHAGUS.2019,32(12):doi:10.1093/dote/doz012.
APA：
Qin, J.,Zhu, H-D,Guo, J-H,Ni, C-F,Wu, P....&Gao-Jun Teng.(2019).Factors associated with overall survival and relief of dysphagia in advanced esophageal cancer patients after I-125 seed-loaded stent placement: a multicenter retrospective analysis.DISEASES OF THE ESOPHAGUS,32,(12)
MLA：
Qin, J.,et al."Factors associated with overall survival and relief of dysphagia in advanced esophageal cancer patients after I-125 seed-loaded stent placement: a multicenter retrospective analysis".DISEASES OF THE ESOPHAGUS 32..12(2019)
