机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China首都医科大学附属北京同仁医院临床科室眼科青光眼一科[2]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院研究所眼科研究所[3]Department of Ophthalmology, University of California, San Francisco, CA, USA[4]Department of Pneumology, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[5]Department of Hyperbaric and Hypobaric Chamber, Civil Aviation General Hospital, Beijing, China
Purpose: To investigate the association between changes in arterial blood gases and intraocular pressure (IOP) after acute, short-term exposure to simulated elevation of 4000 m above sea level. Methods: Twenty-five healthy young lowlanders participated in this prospective study. IOP was measured in both eyes with an Accupen tonometer. Arterial blood gas parameters (partial oxygen pressure [PaO2], partial carbon dioxide pressure [PaCO2], pH, and bicarbonate ion [HCO3-]) were checked using a blood gas analyzer. Measurements were taken at sea level (T1), at 15-minute (T2) and at 2-hour (T3) exposure times to simulated 4000 m above sea level in a hypobaric chamber, and upon return to sea level (T4). Associations between arterial blood gas parameters and IOP were evaluated using multivariate linear regression. Results: PaO2 significantly decreased at T2 and T3, resolving at T4 (P < 0.001). pH significantly increased at T2 and returned to baseline at T3 (P = 0.004). Actual and standard bicarbonate ion both dropped with IOP at T3 and T4. IOP significantly decreased from 16.4 +/- 3.4 mm Hg at T1 to 15.1 +/- 2.1 mm Hg (P = 0.041) at T3 and remained lower (14.9 +/- 2.4 mm Hg; P = 0.029) at T4. IOP was not correlated with pH. Multivariate linear regression showed that lower IOP was associated with lower standard bicarbonate ion (beta = -1.061; 95% confidence interval, -0.049 to -2.074; P = 0.04) when adjusted for actual bicarbonate and diastolic blood pressure. Conclusions: Hypobaric hypoxia triggers plasma bicarbonate ion reduction which, rather than pH, may decrease aqueous humor formation and subsequently cause IOP reduction. These findings may shed light on the mechanism of IOP regulation at high altitude.
基金：
National Natural
Science Foundation of China (81271005 and
81300767), Beijing Natural Science Foundation
(7122038), and The Capital Health Research and
Development of Special Foundation (ZYLX201501).
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China[2]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China[2]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China[*1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang St, Dongcheng District, Beijing, 100730, China
推荐引用方式(GB/T 7714)：
Xie Yuan,Yang Yiquan,Han Ying,et al.Association Between Arterial Blood Gas Variation and Intraocular Pressure in Healthy Subjects Exposed to Acute Short-Term Hypobaric Hypoxia[J].TRANSLATIONAL VISION SCIENCE & TECHNOLOGY.2019,8(6):doi:10.1167/tvst.8.6.22.
APA：
Xie, Yuan,Yang, Yiquan,Han, Ying,Yang, Diya,Sun, Yunxiao...&Wang, Ningli.(2019).Association Between Arterial Blood Gas Variation and Intraocular Pressure in Healthy Subjects Exposed to Acute Short-Term Hypobaric Hypoxia.TRANSLATIONAL VISION SCIENCE & TECHNOLOGY,8,(6)
MLA：
Xie, Yuan,et al."Association Between Arterial Blood Gas Variation and Intraocular Pressure in Healthy Subjects Exposed to Acute Short-Term Hypobaric Hypoxia".TRANSLATIONAL VISION SCIENCE & TECHNOLOGY 8..6(2019)
