Objective: The aim of the current study was to evaluate association levels between POEM scores and arterial blood lactate values, APACHE II scores, and SOFA scores in septic shock patients, validating the predictive value of microcirculation POEM scores for septic shock. Methods: Experimental data was gathered on all patients diagnosed with septic shock in the Emergency Department and ICU of Shanghai Changzheng Hospital, between July 2017 and June 2018. Video-microscopy images of microcirculation at the sub-labial mucosa were captured on the first day, as the final diagnosis of septic shock was made. APACHE II scores and SOFA scores were employed to monitor heart rates, mean arterial pressure, and blood lactate, along with other indicators. Correlation levels between POEM scores and arterial blood lactate values, APACHE II scores, and SOFA scores were investigated via statistical analysis. Moreover, ROC curves were established, aiming to compare the prognostic evaluation of POEM scores, arterial blood lactate, APACHE scores, and SOFA scores for patients with septic shock. Results: POEM scores and APACHE II scores of patients with septic shock showed a negative correlation and a linear correlation, with P = 0.0032 and r = -0.346. POEM scores and SOFA scores showed a negative correlation and a linear correlation, with P = 0.0121 and r = -0.242. POEM scores and blood lactate values showed a negative correlation and a linear correlation, with P = 0.0085 and r = -0.348. ROC curves were also established. They were based on POEM scores, APACHE II scores, SOFA scores, and blood lactate values (within 24 hours), evaluating the prognosis of septic shock. The largest areas under ROC curves were for POEM scores and blood lactic acid, showing 0.841 and 0.823 respectively, indicating that these two parameters provide better predictive value for prognosis evaluation. The optimal cut-off value of POEM scores was 3.5. Moreover, specificity was 77.6%, sensitivity was 88.9%, and the Youden value was 0.655. Conclusion: POEM scores can evaluate patient microcirculation and predict prognosis for septic shock, as with APACHE II scores, SOFA scores, and blood lactate value. The optimal cut-off value was 3.5. Thus, POEM scores may become a new clinical index for condition evaluation and prognosis prediction of septic shock patients.