机构：[1]State Key Laboratory of Bioelectronics, MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 210096, China[2]Zhangjiagang City First People’s Hospital, The Affiliated Zhangjiagang Hospital of Suzhou University, Zhangjiagang 215600, China[3]ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China[4]Department of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211102, China[5]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China[6]Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing, China[7]Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing 100069, China
The transplantation of neural stem cells (NSCs) has become an emerging treatment for neural degeneration. A key factor in such treatments is to manipulate NSC behaviors such as proliferation and differentiation, resulting in the eventual regulation of NSC fate. Novel bionanomaterials have shown usefulness in guiding the proliferation and differentiation of NSCs due to the materials' unique morphological and topological properties. Among the nanomaterials, graphene has drawn increasing attention for neural regeneration applications based on the material's excellent physicochemical properties, surface modifications, and biocompatibility. In this review, we summarize recent works on the use of graphene-based biomaterials for regulating NSC behaviors and the potential use of these materials in clinical treatment. We also discuss the limitations of graphene-based nanomaterials for use in clinical practice. Finally, we provide some future prospects for graphene-based biomaterial applications in neural regeneration.
基金：
Strategic Priority Research Program of the Chinese Academy of ScienceChinese Academy of Sciences [XDA16010303]; National Key R&D Program of China [2017YFA0103903]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81622013, 81570919]; Boehringer Ingelheim Pharma GmbHBoehringer Ingelheim; Huo Yingdong Education Foundation; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Open Research Fund of the State Key Laboratory of Genetic Engineering, Fudan University [SKLGE1809]
第一作者机构：[1]State Key Laboratory of Bioelectronics, MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 210096, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Bioelectronics, MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 210096, China[3]ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China[4]Department of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211102, China[5]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China[6]Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing, China[7]Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Xia Lin,Zhu Wenjuan,Wang Yunfeng,et al.Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials[J].NEURAL PLASTICITY.2019,2019:doi:10.1155/2019/3608386.
APA：
Xia, Lin,Zhu, Wenjuan,Wang, Yunfeng,He, Shuangba&Chai, Renjie.(2019).Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials.NEURAL PLASTICITY,2019,
MLA：
Xia, Lin,et al."Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials".NEURAL PLASTICITY 2019.(2019)
