Hemangioma is a common vascular disease in infants and young children and some tumor masses locate at peculiar sites that damage the function of organs and may even affect development. However, treatment of infantile hemangioma at a peculiar site is not uniform. This study evaluated the clinical efficiency of the treatment 'pingyangmycin-assisted resection'. A total of 129 children with hemangioma at a peculiar site was selected, and were divided into three groups randomly. Simplex surgical removal of tumor (group A), pingyangmycin local injection (group B), and pingyangmycin local injection combined with surgery procedure (group C) were performed. Short-term clinical efficacy, one-year recurrence rate, complication during treatment & adverse drug reaction rate, and protein expression of ER, VEGF and bF-GF in tumor tissue was taken into consideration to evaluate the clinical efficiency. After three courses of treatment, the clinical total effective rate among three groups was significantly different, group C was higher than group B and the cure rate of group C were higher than group A and B (P<0.05). After one-year follow-up visit, the recurrence rate of group C was lower than group A and B (P>0.05). The complication during treatment and adverse drug reaction rate among the three groups was not statistically different and all patients were able to tolerate adverse drug reactions, and the complications disappeared after symptom treatment. The positive expression rate of ER, VEGF, and bF-GF protein in post-treatment tumor tissues of patients in group C was significantly lower than group B and C (P<0.05). Treatment, with local injection of pingyangmycin combined with surgical resection of hemangioma at a peculiar site, can effectively reduce the positive expression of ER, VEGF and bF-GF protein in tumor tissues. Clinical efficacy was solid with lower recurrence rate, and children could tolerate postoperative complications and adverse drug reactions. The results suggest that this treatment approach has high clinical value.