The Association between Metabolic Syndrome and Morbid Events in Type 2 Diabetes after a 7-Year Community Management: Beijing Community Diabetes Study 17
机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Endocrinol, Beijing, Peoples R China临床科室内分泌科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Capital Med Univ, Beijing Ditan Hosp, Dept Med Records & Stat, Beijing, Peoples R China[3]Univ Rochester, Sch Med & Dent, Clin & Translat Sci Inst, Rochester, NY USA[4]Cuigezhuang Community Hlth Serv Ctr, Beijing, Peoples R China[5]Jinsong Community Hlth Serv Ctr, Beijing, Peoples R China[6]Capital Med Univ, Fuxing Hosp, Yuetan Community Hlth Serv Ctr, Beijing, Peoples R China[7]Xinjiekou Community Hlth Serv Ctr, Beijing, Peoples R China[8]Beijing Aerosp Gen Hosp, Dept Endocrinol, Beijing, Peoples R China[9]Aerosp Cent Hosp, Beijing, Peoples R China[10]Sanlitun Community Hlth Serv Ctr, Beijing, Peoples R China[11]Jiangtai Community Hlth Serv Ctr, Beijing, Peoples R China[12]Balizhuang Community Hlth Serv Ctr, Beijing, Peoples R China[13]Zuojiazhuang Community Hlth Serv Ctr, Beijing, Peoples R China[14]Majiapu Community Hlth Serv Ctr, Beijing, Peoples R China[15]Cent Univ Nationalities, Sch Hosp, Beijing, Peoples R China[16]First Peoples Hosp Dongcheng Dist, Beijing, Peoples R China
Background. To examine the association between morbid events and metabolic syndrome (MS) in patients with type 2 diabetes mellitus (T2DM). Methods. A prospective, longitudinal, multicenter study was conducted at 13 community health centers associated with Beijing Tongren Hospital. From 2008 to 2015, there have been 3,525 T2DM patients being managed based on the Chinese guideline for T2DM. The morbid events included macrovascular events, diabetic kidney disease, ophthalmologic events, cancer, and all-cause death. Results. At baseline, there were 2,708 people with MS and 817 without MS. After a seven-year management, there were 351 (12.96%) events in MS people and 74 (9.06%) events in people without MS (p=0.003). The prevalence of macrovascular events (6.06%) was much higher in MS people than in people without MS (3.79%, p=0.013). Cox regression analysis showed an association between MS and morbid events even after adjusting for confounding variables (adjustedhazardratio=1.44). MS was also associated with macrovascular events (adjustedhazardratio=1.96). The occurrence of morbid events and macrovascular events was increased when the numbers of metabolic abnormalities were 1, 2, 3, and 4 (p<0.001). There was no continuously statistically significant difference in the cumulative prevalence of morbid events between patients with MS and patients without MS during the first five years. However, after six or seven years, the cumulative prevalence of morbid events in patients with MS was continuously significantly higher than that in patients without MS (11.00% vs. 8.20%, 12.96% vs. 9.06%, p<0.05). Conclusions. T2DM with MS had higher incidence of morbid events, especially cardiovascular events, even after integrated management. The occurrence of morbid and macrovascular events increased as the number of metabolic abnormalities increased. MS was associated with increased risk of morbid events by 44% and macrovascular events by 96%. It would take at least six years to observe the association between MS and morbid events in T2DM.
基金：
Capital's Funds for Health Improvement and Research [2016-1-2057, 2016-2-2054]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z151100004015021]; Beijing Municipal Training Foundation for Highly Qualified and Technological Talents of Health System [2014-3-013]; University of Rochester's Clinical and Translational Science Award (CTSA) from the National Center for Advancing Translational Sciences of the National Institutes of Health in the USA [UL1 TR000042, UL1 TR002001]; NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR002001] Funding Source: NIH RePORTER
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区医学：研究与实验4 区内分泌学与代谢
最新[2023]版：
大类|3 区医学
小类|3 区内分泌学与代谢3 区医学：研究与实验
JCR分区：
出版当年[2017]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ3ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q2ENDOCRINOLOGY & METABOLISMQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Endocrinol, Beijing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Guang-Ran,Yuan Ming-Xia,Fu Han-Jing,et al.The Association between Metabolic Syndrome and Morbid Events in Type 2 Diabetes after a 7-Year Community Management: Beijing Community Diabetes Study 17[J].JOURNAL OF DIABETES RESEARCH.2019,2019:doi:10.1155/2019/5237371.
APA：
Yang, Guang-Ran,Yuan, Ming-Xia,Fu, Han-Jing,Wan, Gang,Li, Dongmei...&Yuan, Shen-Yuan.(2019).The Association between Metabolic Syndrome and Morbid Events in Type 2 Diabetes after a 7-Year Community Management: Beijing Community Diabetes Study 17.JOURNAL OF DIABETES RESEARCH,2019,
MLA：
Yang, Guang-Ran,et al."The Association between Metabolic Syndrome and Morbid Events in Type 2 Diabetes after a 7-Year Community Management: Beijing Community Diabetes Study 17".JOURNAL OF DIABETES RESEARCH 2019.(2019)
