机构：[1]Departments of General Surgery,Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , China[2]Departments of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , China
Gastric cancer is the fifth most lethal carcinoma in the world. Genetic and epigenetic factors transform the normal cells into malignant cells and lead to tumor development. MicroRNA (miRNA), a small non-coding RNA which functions in RNA silencing and post-transcriptional regulation of gene expression, is closely associated with cancer initiation and propagation, including stomach cancer. In this study, for the first time, we report miR-539-3P, as a tumor suppressor, was down-regulated in gastric cancer both in vivo and in vitro. In addition, dysfunction of miR-539-3P regulates gastric cancer cell proliferation and invasion. Bioinformatics analysis revealed CTBP1 is the direct target of miR-539-3P and high expression of CTBP1 faciliates the progression of gastric carcinoma through promoting the epithelial to mesenchymal transition (EMT). Overall, these results indicate that epigenetic regulation of CTBP1 through miR-539-3P is critical to gastric cancer and provide a new insight into gastric cancer diagnosis, treatment and prognosis.
基金：
Shanghai Key
Specialty-General Surgery Project (No. ZK20-
15A25).
第一作者机构：[1]Departments of General Surgery,Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , China
通讯作者：
通讯机构：[1]Departments of General Surgery,Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , China[*1]Department of General Surgery, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, 1111 Xianxia Road, Shanghai 200336, China
推荐引用方式(GB/T 7714)：
Zhou Jia,Su Mingqi,Zhang Hui,et al.miR-539-3P inhibits proliferation and invasion of gastric cancer cells by targeting CTBP1[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2019,12(5):1618-1625.
APA：
Zhou, Jia,Su, Mingqi,Zhang, Hui,Wang, Jialiang&Chen, Ying.(2019).miR-539-3P inhibits proliferation and invasion of gastric cancer cells by targeting CTBP1.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,12,(5)
MLA：
Zhou, Jia,et al."miR-539-3P inhibits proliferation and invasion of gastric cancer cells by targeting CTBP1".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 12..5(2019):1618-1625
