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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

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机构: [1]NHGRI, Ctr Res Genom & Global Hlth, US Natl Inst Hlth, Bethesda, MD 20892 USA [2]Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA [3]Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Dept Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Houston, TX 77030 USA [4]Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany [5]Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA [6]Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Clin Pharmacol, London, England [7]Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA [8]Harvard Med Sch, Boston, MA 02115 USA [9]Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA [10]Harbor UCLA Med Ctr, Dept Pediat, Inst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA [11]Womens Hlth Initiat Clin Coordinating Ctr, Fred Hutchinson Canc Res Ctr, Seattle, WA USA [12]Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA [13]Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore [14]Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Ctr Quantitat Med, Acad Med Res Inst, Singapore, Singapore [15]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore [16]Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore [17]Natl Univ Hlth Syst, Singapore, Singapore [18]Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands [19]Univ Edinburgh, Inst Genet & Mol Med, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland [20]Univ Mississippi, Med Ctr, Dept Med, Jackson Heart Study, Jackson, MS 39216 USA [21]Univ Georgia, Athens Coll Publ Hlth, Epidemiol & Biostat, Athens, GA 30602 USA [22]Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Houston, TX 77030 USA [23]Leiden Univ, Med Ctr, Internal Med Gerontol & Geriatr, Leiden, Netherlands [24]Inst Pasteur, C3BI, Paris, France [25]Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA [26]Univ Washington, Dept Biostat, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA [27]Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA [28]Wake Forest Univ Hlth Sci, Ctr Diabet Obes & Metab Gerontol & Geriatr Med, Winston Salem, NC USA [29]Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore [30]Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA [31]Harvard Med Sch, Dept Med, Boston, MA 02115 USA [32]Pennington Biomed Res Ctr, Human Genom Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA [33]Iceland Heart Assoc, Kopavogur, Iceland [34]Univ Iceland, Fac Med, Reykjavik, Iceland [35]NIA, Hlth Dispar Res Sect, Lab Epidemiol & Populat Sci, US Natl Inst Hlth, Baltimore, MD 21224 USA [36]Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA [37]Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA [38]Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia [39]Univ Lille, European Genom Inst Diabet, Inst Pasteur Lille, CNRS UMR 8199, Lille, France [40]Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden [41]Wake Forest Sch Med, Dept Biostat & Data Sci, Div Publ Hlth Sci, Winston Salem, NC USA [42]Imperial Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England [43]Univ Ioannina, Med Sch, Dept Hyg & Epidemiol, Ioannina, Greece [44]Wake Forest Sch Med, Mol Genet & Genom Program, Winston Salem, NC USA [45]Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England [46]Univ Oxford, Wellcome Ctr Human Genet, Oxford, England [47]Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands [48]Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland [49]Univ Edinburgh, Ctr Genom & Expt Med, Med Genet Sect, Edinburgh, Midlothian, Scotland [50]Univ Fed Pelotas, Postgrad Programme Epidemiol, Pelotas, Brazil [51]Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England [52]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Occupat & Environm Hlth, Wuhan, Hubei, Peoples R China [53]Huazhong Univ Sci & Technol, Tongji Med Coll, State Key Lab Environm Hlth Incubating, Wuhan, Hubei, Peoples R China [54]Univ Sao Paulo, Heart Inst InCor, Lab Genet & Mol Cardiol, Med Sch, Sao Paulo, Brazil [55]Triserv Gen Hosp, Endocrinol & Metab, Taipei, Taiwan [56]Natl Def Med Ctr, Sch Med, Taipei, Taiwan [57]Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA [58]Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA [59]Univ Kelaniya, Fac Med, Dept Publ Hlth, Ragama, Sri Lanka [60]Kuopio Res Inst Exercise Med, Fdn Res Hlth Exercise & Nutr, Kuopio, Finland [61]Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm, Neuherberg, Germany [62]Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm, Neuherberg, Germany [63]Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Stockholm, Sweden [64]Taichung Vet Gen Hosp, Ophthalmol, Taichung, Taiwan [65]Univ Cambridge, Med Res Council, Epidemiol Unit, Cambridge, England [66]Fimlab Labs, Dept Clin Chem, Tampere, Finland [67]Tampere Univ, Fac Med & Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland [68]RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan [69]Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands [70]DZHK German Ctr Cardiovasc Hlth, Partner Site Greifswald, Greifswald, Germany [71]Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany [72]Wellcome Trust Sanger Inst, Human Genet, Hinxton, England [73]Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England [74]Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England [75]IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy [76]Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Med Ctr, New York, NY USA [77]Brigham & Womens Hosp, Div Sleep & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA [78]Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland [79]Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo, Japan [80]Loyola Univ Chicago, Dept Publ Hlth Sci, Maywood, IL USA [81]Lund Univ Diabet Ctr, Skane Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden [82]Natl Taiwan Univ Hosp, Cardiovasc Ctr, Taipei, Taiwan [83]Natl Taiwan Univ, Coll Med, Taipei, Taiwan [84]Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei, Taiwan [85]Case Western Reserve Univ, Dept Populat Quantitat & Hlth Sci, Cleveland, OH 44106 USA [86]Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48109 USA [87]Vanderbilt Univ, Sch Med, Div Epidemiol, Dept Med, Nashville, TN 37212 USA [88]Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, SKLORG,Sch Med, Shanghai, Peoples R China [89]Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, Dept Epidemiol,Sch Med, Shanghai, Peoples R China [90]Johns Hopkins Univ, Sch Med, Dept Med, Div Gen Internal Med, Baltimore, MD 21205 USA [91]Imperial Coll, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England [92]Ealing Gen Hosp, Dept Cardiol, Southall, Middx, England [93]Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Sch Med, Baltimore, MD USA [94]Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore [95]Baylor Coll Med, Sect Cardiovasc Res, Houston, TX 77030 USA [96]Houston Methodist Debakey Heart & Vasc Ctr, Houston, TX USA [97]Columbia Univ, Med Ctr, Dept Med, New York, NY USA [98]Columbia Univ, Med Ctr, Dept Epidemiol, New York, NY USA [99]Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA [100]Med Coll Wisconsin, Dept Pediat, Sect Genom Pediat, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA [101]Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA [102]Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA [103]Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, London, England [104]Univ Edinburgh, Ctr Genom & Expt Med, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland [105]Univ Southern Denmark, Danish Aging Res Ctr, Inst Publ Hlth, Odense, Denmark [106]Univ Dundee, Ninewells Hosp & Med Sch, Dundee, Scotland [107]Washington Univ, Sch Med, Dept Med, Cardiovasc Div, St Louis, MO 63110 USA [108]Univ Kelaniya, Fac Med, Dept Med, Ragama, Sri Lanka [109]Univ North Carolina Chapel Hill, Dept Genet, Chapel Hill, NC USA [110]Brown Univ, Alpert Med Sch, Dept Family Med & Epidemiol, Providence, RI 02912 USA [111]Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA [112]Univ West Indies, UWI Solut Developing Countries, Kingston, Jamaica [113]Hebrew Univ Jerusalem, Braun Sch Publ Hlth, Hadassah Med Ctr, Jerusalem, Israel [114]Univ Trieste, Dept Med Sci, Trieste, Italy [115]Mashhad Univ Med Sci, Sch Med, Dept Genet, Mashhad, Razavi Khorasan, Iran [116]Univ Washington, UW Med Sleep Ctr, Dept Med, Ctr Lung Biol, Seattle, WA 98195 USA [117]Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany [118]NIA, Lab Epidemiol & Populat Sci, US Natl Inst Hlth, Bethesda, MD 20892 USA [119]Univ Eastern Finland, Sch Med, Inst Biomed, Kuopio, Finland [120]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore [121]Khoo Teck Puat Natl Univ, Natl Univ Hlth Syst, Childrens Med Inst, Singapore, Singapore [122]Univ Tokyo, Human Genome Ctr, Inst Med Sci, Lab Genome Technol,Minato Ku, Tokyo, Japan [123]Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands [124]Erasmus MC, Dept Neurol, Rotterdam, Netherlands [125]Harvard Med Sch, Beth Israel Deaconess Med Ctr, Hebrew SeniorLife, Boston, MA 02115 USA [126]NHLBI, Framingham Heart Study, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA [127]Univ Washington, Collaborat Hlth Studies Coordinating Ctr, Seattle, WA 98195 USA [128]Heidelberg Univ, Med Fac Mannhe, Dept Ophthalmol, Mannheim, Germany [129]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China [130]Osaka Univ, Dept Clin Gene Therapy, Grad Sch Med, Suita, Osaka, Japan [131]Osaka Univ, Dept Geriatr & Gen Med, Grad Sch Med, Suita, Osaka, Japan [132]Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, Fac Hlth & Med Sc, Copenhagen, Denmark [133]Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA [134]Duke NUS Med Sch, Singapore, Singapore [135]Univ Split, Dept Publ Hlth, Dept Med, Split, Croatia [136]Univ Washington, Fred Hutchinson Canc Res Ctr, Sch Publ Hlth, Seattle, WA 98195 USA [137]Wake Forest Sch Med, Sticht Ctr Hlth Aging & Alzheimers Prevent, Dept Internal Med, Winston Salem, NC USA [138]RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan [139]Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland [140]Imperial Coll, Inst Clin Sci, Dept Mol Sci, London, England [141]Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA [142]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore [143]Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Epidemiol, Chicago, IL 60611 USA [144]Agcy Sci Technol & Res, Translat Lab Genet Med, Singapore, Singapore [145]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore [146]Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore [147]Univ Washington, Dept Biostat, Seattle, WA 98195 USA [148]Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA [149]Univ West Indies, Caribbean Inst Hlth Res, Trop Metab Res Unit, Mona, Jamaica [150]Helmholtz Zentrum Munchen, Inst Human Genet, German Res Ctr Environm, Neuherberg, Germany [151]Tech Univ Munich, Inst Human Genet, Munich, Germany [152]Tech Univ Munich, Munich, Germany [153]Vrije Univ, Amsterdam Univ Med Ctr, Dept Psychiat, Amsterdam, Netherlands [154]RIKEN Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa, Japan [155]Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England [156]Univ Aberdeen, Aberdeen Biomed Imaging Ctr, Inst Med Sci, Aberdeen, Scotland [157]Data Tecn Int, Glen Echo, MD USA [158]NIA, Lab Neurogenet, Bethesda, MD 20892 USA [159]Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA [160]Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA [161]Wake Forest Sch Med, Biochem, Winston Salem, NC USA [162]NHLBI, Epidemiol Branch, Div Cardiovasc Sci, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA [163]Ludwig Maximilians Univ Munchen, Fac Med, Inst Med Informat Proc, Epidemiol, Munich, Germany [164]Psychiat Hosp Sveti Ivan, Zagreb, Croatia [165]Geninfo Ltd, Zagreb, Croatia [166]Imperial Coll, Sch Publ Hlth, London, England [167]Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland [168]Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland [169]Umea Univ, Dept Biobank Res, Umea, Sweden [170]Univ Iowa, Dept Epidemiol & Med, Iowa City, IA USA [171]Leiden Univ, Clin Epidemiol, Med Ctr, Leiden, Netherlands [172]Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland [173]Univ Med Greifswald, Inst Community Med, Greifswald, Germany [174]Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA [175]Imperial Coll, Natl Heart & Lung Inst, London, England [176]Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA [177]Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland [178]Helmholtz Zentrum Munchen, Inst Genet Epidemiol, German Res Ctr Environm, Neuherberg, Germany [179]Stanford Univ, Dept Genet, Stanford, CA 94305 USA [180]Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore, Singapore [181]Natl Univ Singapore, Life Sci Inst, Singapore, Singapore [182]Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore, Singapore [183]Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA [184]Mayo Clin, Div Nephrol & Hypertens, Rochester, MN USA [185]Erasmus MC, Dept Internal Med, Rotterdam, Netherlands [186]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China [187]Jackson State Univ, Sch Publ Hlth, Jackson Heart Study, Jackson, MS USA [188]Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA [189]Univ Pittsburgh, Div Canc Control & Populat Sci, UPMC Hillman Canc, Pittsburgh, PA USA [190]NIA, Behav Epidemiol Sect, Lab Epidemiol & Populat Sci, US Natl Inst Hlth, Baltimore, MD 21224 USA [191]Imperial Coll Healthcare NHS Trust, London, England [192]Univ Edinburgh, Psychol, Edinburgh, Midlothian, Scotland [193]Broad Inst MIT & Harvard, Boston, MA USA [194]Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA [195]Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden [196]Univ Oxford, Radcliffe Dept Med, OCDEM, Oxford, England [197]Wake Forest Sch Med, Internal Med, Nephrol, Winston Salem, NC USA [198]Imperial Coll, Dept Genom Common Dis, London, England [199]German Ctr Diabet Res DZD, Neuherberg, Germany [200]Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA [201]Taichung Vet Gen Hosp, Internal Med, Endocrinol & Metab, Taichung, Taiwan [202]Chung Shan Med Univ, Sch Med, Taichung, Taiwan [203]Natl Yang Ming Univ, Sch Med, Taipei, Taiwan [204]Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands [205]Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands [206]Wake Forest Sch Med, Publ Hlth Sci, Winston Salem, NC USA [207]Helmholtz Zentrum Munchen, Inst Translat Genom, German Res Ctr Environm, Neuherberg, Germany [208]Wake Forest Univ Hlth Sci, Epidemiol & Prevent, Publ Hlth Sci, Winston Salem, NC USA [209]Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA [210]Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA [211]Leiden Univ, Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands [212]Tulane Univ, Sch Publ Hlth & Trop Med, Epidemiol, New Orleans, LA 70118 USA [213]Univ Mississippi, Med Ctr, Cardiol, Med, Jackson, MS 39216 USA [214]Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England [215]Icahn Sch Med Mt Sinai, Mindich Child Hlth Dev Inst, New York, NY 10029 USA [216]Washington Univ, Sch Med, Psychiat, St Louis, MO USA [217]Univ Southern Calif, Dept Prevent Med, Biostat, Los Angeles, CA USA
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摘要:
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

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出版当年[2018]版:
大类 | 1 区 生物
小类 | 1 区 遗传学
最新[2025]版:
大类 | 1 区 生物学
小类 | 1 区 遗传学
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出版当年[2017]版:
Q1 GENETICS & HEREDITY
最新[2023]版:
Q1 GENETICS & HEREDITY

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第一作者:
第一作者机构: [1]NHGRI, Ctr Res Genom & Global Hlth, US Natl Inst Hlth, Bethesda, MD 20892 USA
通讯作者:
通讯机构: [9]Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA [126]NHLBI, Framingham Heart Study, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
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