Aims: Severe acute pancreatitis (SAP) is an acute disease of the digestive system accompanied by pancreatic necrosis. We have found that bone marrow-derived mesenchymal stem cells (BMSCs) can attenuate SAP, but the underlying mechanism remains unclear. The present study was conducted to explore the possible mechanisms by which BMSCs alleviate SAP. Main methods: BMSCs and BMSCs engineered to overexpress microRNA (miR)-9 (miR-9-BMSCs) were transplanted into rat models of SAP via the tail vein. Pancreatic acinar cells (PACs) were isolated from rat pancreatic tissues and induced by tumor necrosis factor-alpha (TNF-alpha) in vitro. Key findings: miR-9-BMSCs significantly reduced the systemic inflammatory response, impeded the necroptosis signaling pathway and promoted regeneration of damaged pancreas in vivo. miR-9-BMSCs secreted miR-9, which targeted the gene encoding receptor interacting protein kinase 1 in PACs induced by TNF-alpha, to inhibit necroptosis and ameliorate SAP. Significance: miR-9-BMSCs can reduce SAP-induced injury to pancreatic tissues and PACs by regulating miR-9 to suppress necroptosis.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670582]; College Natural Science Foundation of Anhui ProvinceNatural Science Foundation of Anhui Province [KJ2017A271]; talent introduction fund of Yijishan Hospital of Wannan Medical School [YR201601]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2023]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2017]版：
Q2PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Tongji Univ, Shanghai Peoples Hosp 10, Dept Gen Surg, Sch Med, Yanchang Rd 301, Shanghai 200072, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Tongji Univ, Shanghai Peoples Hosp 10, Dept Gen Surg, Sch Med, Yanchang Rd 301, Shanghai 200072, Peoples R China[*1]Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Yanchang Road 301, Shanghai 200072, China.
推荐引用方式(GB/T 7714)：
Song Guodong,Ma Zhilong,Liu Dalu,et al.Bone marrow-derived mesenchymal stem cells attenuate severe acute pancreatitis via regulation of microRNA-9 to inhibit necroptosis in rats[J].LIFE SCIENCES.2019,223:9-21.doi:10.1016/j.lfs.2019.03.019.
APA：
Song, Guodong,Ma, Zhilong,Liu, Dalu,Qian, Daohai,Zhou, Jia...&Song, Zhenshun.(2019).Bone marrow-derived mesenchymal stem cells attenuate severe acute pancreatitis via regulation of microRNA-9 to inhibit necroptosis in rats.LIFE SCIENCES,223,
MLA：
Song, Guodong,et al."Bone marrow-derived mesenchymal stem cells attenuate severe acute pancreatitis via regulation of microRNA-9 to inhibit necroptosis in rats".LIFE SCIENCES 223.(2019):9-21
医学