机构：[1]Shanghai Putuo District Central Hospital, Shanghai, China[2]Department of Diagnostic Ultrasound, Tong Ren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
BACKGROUND: Breast cancer is the most common cancer in women worldwide. The purpose of the study was to observe the features of contrast-enhanced ultrasound (CEUS) and the combination with Breast Imaging-Reporting and Data System (BI-RADS) of conventional ultrasound for assessing small breast lesions. OBJECTIVES: The study was to explore the small breast lesions' features of contrast-enhanced ultrasound (CEUS) and the combination with Breast Imaging-Reporting and Data System (BI-RADS) of conventional ultrasound, in order to improve the diagnostic accuracy of early breast cancer. METHODS: 105 lesions were subject to conventional US (ultrasound) and CEUS before operations or biopsies. Among 105 breast lesions, six patient diagnoses were established by thick core-needle biopsy, while the rest were all confirmed by surgery and pathology. RESULTS: Significant differences were found between benign and malignant lesions in qualitative and quantitative indexes (peak) of CEUS (P < 0.05). The qualitative features of malignant small breast lesions were as follows: (1) enhanced intensity within the lesion was not uniform (61/61,100%); (2) the speed of wash-in was earlier than the surrounding tissue (58/61, 95.1%); (3) lesion interior and the surrounding tissues had contrast vessel performance (61/61,100%). Peak of malignant lesions (35.77 +/- 11.45) was higher than that of benign lesions (31.96 +/- 10.76) (P < 0.05). The diagnostic performance of BI-RADS-US plus qualitative indexes (method one) in terms of area under receiver operating characteristic curve (AUROC) were the highest (i.e., AUROC = 0.817), in comparison with other combined diagnostic methods. The associated sensitivity, specificity and accuracy were 78.69%, 84.09% and 80.95%, respectively. With method one, however, was similar with USBI-RADS in specificity, 11 malignant breast lesions were regarded as a higher classification of BI-RADS and classified into malignant group, which were identified as benign on US-BI-RADS originally. CONCLUSIONS: CEUS was useful to differentiate benign from malignant small breast lesions, and the combination of CEUS and BI-RADS-US can improve the early diagnosis of breast cancers.
基金：
National Natural Science Foundation of China (NSFC) [81470079, 81172078]; Scientific research project of the Shanghai municipal health and Planning Committee [20164Y0162]
第一作者机构：[1]Shanghai Putuo District Central Hospital, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Diagnostic Ultrasound, Tong Ren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China[*1]Department of Diagnostic Ultrasound, Tong Ren Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1111 Xian Xia Road, Shanghai 200336, China.
推荐引用方式(GB/T 7714)：
Du Yan-Ran,Wu Yang,Chen Man,et al.Application of contrast-enhanced ultrasound in the diagnosis of small breast lesions[J].CLINICAL HEMORHEOLOGY AND MICROCIRCULATION.2018,70(3):291-300.doi:10.3233/CH-170368.
APA：
Du, Yan-Ran,Wu, Yang,Chen, Man&Gu, Xin-Gang.(2018).Application of contrast-enhanced ultrasound in the diagnosis of small breast lesions.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,70,(3)
MLA：
Du, Yan-Ran,et al."Application of contrast-enhanced ultrasound in the diagnosis of small breast lesions".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 70..3(2018):291-300
