资源类型:
期刊
WOS体系:
Article
Pubmed体系:
Journal Article;Research Support, Non-U.S. Gov't
收录情况:
◇ SCIE
◇ 自然指数
文章类型:
论著
作者:
Takeuchi, Fumihiko[1,2]
*
;
Akiyama, Masato[3]
*
;
Matoba, Nana[3]
*
;
Katsuya, Tomohiro[4,5]
*
;
Nakatochi, Masahiro[6]
*
;
Tabara, Yasuharu[7]
*
;
Narita, Akira[8]
;
Saw, Woei-Yuh[9,10,11]
;
Moon, Sanghoon[12]
;
Spracklen, Cassandra N.[13]
;
Chai, Jin-Fang[9,10]
;
Kim, Young-Jin[12]
;
Zhang, Liang[14]
;
Wang, Chaolong[15,16,17]
;
Li, Huaixing[18]
;
Li, Honglan[19,20]
;
Wu, Jer-Yuarn[21,22]
;
Dorajoo, Rajkumar[15]
;
Nierenberg, Jovia L.[23]
;
Wang, Ya Xing[24]
;
He, Jing[25]
;
Bennett, Derrick A.[26,27]
;
Takahashi, Atsushi[3,28]
;
Momozawa, Yukihide[29]
;
Hirata, Makoto[30]
;
Matsuda, Koichi[31]
;
Rakugi, Hiromi[5]
;
Nakashima, Eitaro[32,33]
;
Isono, Masato[2]
;
Shirota, Matsuyuki[8]
;
Hozawa, Atsushi[8]
;
Ichihara, Sahoko[34]
;
Matsubara, Tatsuaki[35]
;
Yamamoto, Ken[36]
;
Kohara, Katsuhiko[37]
;
Igase, Michiya[38]
;
Han, Sohee[12]
;
Gordon-Larsen, Penny[39,40]
;
Huang, Wei[41,42]
;
Lee, Nanette R.[43,44]
;
Adair, Linda S.[39,40]
;
Hwang, Mi Yeong[12]
;
Lee, Juyoung[12]
;
Chee, Miao Li[14]
;
Sabanayagam, Charumathi[14,45,46]
;
Zhao, Wanting[14,16]
;
Liu, Jianjun[15,47]
;
Reilly, Dermot F.[48]
;
Sun, Liang[18]
;
Huo, Shaofeng[18]
;
Edwards, Todd L.[25]
;
Long, Jirong[25]
;
Chang, Li-Ching[21]
;
Chen, Chien-Hsiun[21]
;
Yuan, Jian-Min[49,50]
;
Koh, Woon-Puay[9,10,51]
;
Friedlander, Yechiel[52]
;
Kelly, Tanika N.[23]
;
Wei, Wen Bin[53]
;
Xu, Liang[24]
;
Cai, Hui[25]
;
Xiang, Yong-Bing[19,20]
;
Lin, Kuang[26,27]
;
Clarke, Robert[26,27]
;
Walters, Robin G.[26,27]
;
Millwood, Iona Y.[26,27,54]
;
Li, Liming[55,56]
;
Chambers, John C.[57]
;
Kooner, Jaspal S.[58]
;
Elliott, Paul[59,60,61,62,63]
;
van der Harst, Pim[64]
;
Chen, Zhengming[26,27]
;
Sasaki, Makoto[65]
;
Shu, Xiao-Ou[25]
;
Jonas, Jost B.[24,66]
;
He, Jiang[23,67]
;
Heng, Chew-Kiat[68,69]
;
Chen, Yuan-Tsong[21]
;
Zheng, Wei[25]
;
Lin, Xu[18]
;
Teo, Yik-Ying[9,10,11,70]
;
Tai, E-Shyong[9,10,16,47]
;
Cheng, Ching-Yu[14,45,46]
;
Wong, Tien Yin[14,45,46]
;
Sim, Xueling[9,10]
;
Mohlke, Karen L.[13]
;
Yamamoto, Masayuki[8]
;
Kim, Bong-Jo[12]
;
Miki, Tetsuro[38]
;
Nabika, Toru[71]
;
Yokota, Mitsuhiro[72]
;
Kamatani, Yoichiro[3,73]
;
Kubo, Michiaki[74]
;
Kato, Norihiro[1,2]
;
机构:
[1]Natl Ctr Global Hlth & Med, Med Genom Ctr, Tokyo 1628655, Japan
[2]Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo 1628655, Japan
[3]RIKEN, Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa 2300045, Japan
[4]Osaka Univ, Grad Sch Med, Dept Clin Gene Therapy, Suita, Osaka 5650871, Japan
[5]Osaka Univ, Grad Sch Med, Dept Geriatr & Gen Med, Suita, Osaka 5650871, Japan
[6]Nagoya Univ Hosp, Dept Adv Med, Data Coordinating Ctr, Nagoya, Aichi 4668560, Japan
[7]Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto 6068507, Japan
[8]Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi 9808573, Japan
[9]Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore
[10]Natl Univ Hlth Syst, Singapore 117549, Singapore
[11]Natl Univ Singapore, Life Sci Inst, Singapore 117456, Singapore
[12]Natl Inst Hlth, Div Genome Res, Ctr Genome Sci, Cheongwon Gun 363951, Chungcheongbuk, South Korea
[13]Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
[14]Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 168751, Singapore
[15]Agcy Sci Technol & Res, Genome Inst Singapore, Singapore 138672, Singapore
[16]Duke NUS Med Sch, Singapore 169857, Singapore
[17]Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Dept Epidemiol & Biostat, Wuhan 430030, Hubei, Peoples R China
[18]Chinese Acad Sci, Univ Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
[19]Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogene & Related Genes, Shanghai Canc Inst,Renji Hosp, Shanghai 200025, Peoples R China
[20]Shanghai Jiao Tong Univ, Sch Med, Dept Epidemiol, Shanghai Canc Inst,Renji Hosp, Shanghai 200025, Peoples R China
[21]Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan
[22]China Med Univ, Sch Chinese Med, Taichung 40402, Taiwan
[23]Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA 70112 USA
[24]Capital Med Univ, Beijing Tongren Hosp, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Inst Ophthalmol,Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China
研究所
眼科研究所
首都医科大学附属北京同仁医院
首都医科大学附属同仁医院
[25]Vanderbilt Univ, Med Ctr, Div Epidemiol, Nashville, TN 37203 USA
[26]Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford OX3 7LF, England
[27]Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford OX3 7LF, England
[28]Natl Cerebral & Cardiovasc Ctr, Res Inst, Dept Genom Med, Osaka 5650873, Japan
[29]RIKEN, Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa 2300045, Japan
[30]Univ Tokyo, Inst Med Sci, Tokyo 1088639, Japan
[31]Univ Tokyo, Grad Sch Frontier Sci, Kashiwa, Chiba 2778561, Japan
[32]Nagoya Univ, Grad Sch Med, Dept Internal Med, Div Endocrinol & Diabet, Nagoya, Aichi 4668550, Japan
[33]Chubu Rosai Hosp, Dept Diabet & Endocrinol, Nagoya, Aichi 4558530, Japan
[34]Jichi Med Univ, Sch Med, Dept Environm & Prevent Med, Shimotsuke 3290498, Japan
[35]Aichi Gakuin Univ, Sch Dent, Dept Internal Med, Nagoya, Aichi 4700195, Japan
[36]Kurume Univ, Sch Med, Dept Med Biochem, Kurume, Fukuoka 8300011, Japan
[37]Ehime Univ, Fac Collaborat Reg Innovat, Matsuyama, Ehime 7908577, Japan
[38]Ehime Univ, Grad Sch Med, Dept Geriatr Med, Toon, Ehime 7910295, Japan
[39]Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA
[40]Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27516 USA
[41]Chinese Natl Human Genome Ctr, Shanghai MOST Key Lab Hlth & Dis Genom, Dept Genet, Shanghai 201203, Peoples R China
[42]Shanghai Ind Technol Inst, Shanghai 201203, Peoples R China
[43]Univ San Carlos, USC Off Populat Studies Fdn, Cebu 6000, Philippines
[44]Univ San Carlos, Dept Anthropol Sociol & Hist, Cebu 6000, Philippines
[45]Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore
[46]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 119228, Singapore
[47]Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117597, Singapore
[48]Merck Sharp Dohme Corp, Kenilworth, NJ 07033 USA
[49]Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA
[50]Univ Pittsburgh, UPMC Hillman Canc, Div Canc Control & Populat Sci, Pittsburgh, PA 15232 USA
[51]Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore 169857, Singapore
[52]Hebrew Univ Jerusalem, Hadassah Braun Sch Publ Hlth, Unit Epidemiol, POB 12272, Jerusalem, Israel
[53]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China
首都医科大学附属北京同仁医院
首都医科大学附属同仁医院
[54]Univ Oxford, Nuffield Dept Populat Hlth, MRC Populat Hlth Res Unit, Oxford OX3 7LF, England
[55]Chinese Acad Med Sci, Beijing 100006, Peoples R China
[56]Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
[57]Imperial Coll London, Dept Epidemiol & Biostat, London SW7 2AZ, England
[58]Imperial Coll London, Natl Heart & Lung Inst, London SW7 2AZ, England
[59]Imperial Coll London, Fac Med, Med Res Council Publ Hlth England MRC PHE Ctr Env, Dept Epidemiol & Biostat,Sch Publ Hlth, London SW7 2AZ, England
[60]Imperial Coll London, Imperial Coll Biomed Res Ctr, London SW7 2AZ, England
[61]Imperial Coll London, UK Dementia Res Inst, London SW7 2AZ, England
[62]Natl Inst Hlth Res NIHR Hlth Protect Res Unit Hlt, London SW7 2AZ, England
[63]Hlth Data Res UK London, London, England
[64]Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands
[65]Iwate Tohoku Med Megabank Org, Yahaba, Iwate 0283694, Japan
[66]Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, D-68167 Mannheim, Germany
[67]Tulane Univ, Sch Med, Dept Med, New Orleans, LA 70112 USA
[68]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore 119228, Singapore
[69]Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ Childrens Med Inst, Singapore 119228, Singapore
[70]Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 119077, Singapore
[71]Shimane Univ, Fac Med, Dept Funct Pathol, Izumo, Shimane 6930021, Japan
[72]Aichi Gakuin Univ, Sch Dent, Dept Genome Sci, Nagoya, Aichi 4648650, Japan
[73]Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto 6068501, Japan
[74]RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan
ISSN:
2041-1723
摘要:
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP ( max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
被引次数:
77
WOS:
WOS:000451433800022
PubmedID:
30487518
中科院(CAS)分区:
出版当年[2017]版:
大类
|
1 区
综合性期刊
小类
|
1 区
综合性期刊
最新[2023]版:
大类
|
1 区
综合性期刊
小类
|
1 区
综合性期刊
JCR分区:
出版当年[2016]版:
Q1
MULTIDISCIPLINARY SCIENCES
最新[2023]版:
Q1
MULTIDISCIPLINARY SCIENCES
影响因子:
14.7
最新[2023版]
16.1
最新五年平均
12.124
出版当年[2016版]
13.092
出版当年五年平均
11.329
出版前一年[2015版]
12.353
出版后一年[2017版]
第一作者:
Takeuchi, Fumihiko
第一作者机构:
[1]Natl Ctr Global Hlth & Med, Med Genom Ctr, Tokyo 1628655, Japan
[2]Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo 1628655, Japan
共同第一作者:
Akiyama, Masato;Matoba, Nana;Katsuya, Tomohiro;Nakatochi, Masahiro;Tabara, Yasuharu
通讯作者:
Kato, Norihiro
通讯机构:
[1]Natl Ctr Global Hlth & Med, Med Genom Ctr, Tokyo 1628655, Japan
[2]Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo 1628655, Japan
推荐引用方式(GB/T 7714):
Takeuchi Fumihiko,Akiyama Masato,Matoba Nana,et al.Interethnic analyses of blood pressure loci in populations of East Asian and European descent[J].NATURE COMMUNICATIONS.2018,9:doi:10.1038/s41467-018-07345-0.
APA:
Takeuchi, Fumihiko,Akiyama, Masato,Matoba, Nana,Katsuya, Tomohiro,Nakatochi, Masahiro...&Kato, Norihiro.(2018).Interethnic analyses of blood pressure loci in populations of East Asian and European descent.NATURE COMMUNICATIONS,9,
MLA:
Takeuchi, Fumihiko,et al."Interethnic analyses of blood pressure loci in populations of East Asian and European descent".NATURE COMMUNICATIONS 9.(2018)