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Interethnic analyses of blood pressure loci in populations of East Asian and European descent

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收录情况: ◇ SCIE ◇ 自然指数

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机构: [1]Natl Ctr Global Hlth & Med, Med Genom Ctr, Tokyo 1628655, Japan [2]Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo 1628655, Japan [3]RIKEN, Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa 2300045, Japan [4]Osaka Univ, Grad Sch Med, Dept Clin Gene Therapy, Suita, Osaka 5650871, Japan [5]Osaka Univ, Grad Sch Med, Dept Geriatr & Gen Med, Suita, Osaka 5650871, Japan [6]Nagoya Univ Hosp, Dept Adv Med, Data Coordinating Ctr, Nagoya, Aichi 4668560, Japan [7]Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto 6068507, Japan [8]Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi 9808573, Japan [9]Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore [10]Natl Univ Hlth Syst, Singapore 117549, Singapore [11]Natl Univ Singapore, Life Sci Inst, Singapore 117456, Singapore [12]Natl Inst Hlth, Div Genome Res, Ctr Genome Sci, Cheongwon Gun 363951, Chungcheongbuk, South Korea [13]Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA [14]Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 168751, Singapore [15]Agcy Sci Technol & Res, Genome Inst Singapore, Singapore 138672, Singapore [16]Duke NUS Med Sch, Singapore 169857, Singapore [17]Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Dept Epidemiol & Biostat, Wuhan 430030, Hubei, Peoples R China [18]Chinese Acad Sci, Univ Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China [19]Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogene & Related Genes, Shanghai Canc Inst,Renji Hosp, Shanghai 200025, Peoples R China [20]Shanghai Jiao Tong Univ, Sch Med, Dept Epidemiol, Shanghai Canc Inst,Renji Hosp, Shanghai 200025, Peoples R China [21]Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan [22]China Med Univ, Sch Chinese Med, Taichung 40402, Taiwan [23]Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA 70112 USA [24]Capital Med Univ, Beijing Tongren Hosp, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Inst Ophthalmol,Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China [25]Vanderbilt Univ, Med Ctr, Div Epidemiol, Nashville, TN 37203 USA [26]Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford OX3 7LF, England [27]Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford OX3 7LF, England [28]Natl Cerebral & Cardiovasc Ctr, Res Inst, Dept Genom Med, Osaka 5650873, Japan [29]RIKEN, Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa 2300045, Japan [30]Univ Tokyo, Inst Med Sci, Tokyo 1088639, Japan [31]Univ Tokyo, Grad Sch Frontier Sci, Kashiwa, Chiba 2778561, Japan [32]Nagoya Univ, Grad Sch Med, Dept Internal Med, Div Endocrinol & Diabet, Nagoya, Aichi 4668550, Japan [33]Chubu Rosai Hosp, Dept Diabet & Endocrinol, Nagoya, Aichi 4558530, Japan [34]Jichi Med Univ, Sch Med, Dept Environm & Prevent Med, Shimotsuke 3290498, Japan [35]Aichi Gakuin Univ, Sch Dent, Dept Internal Med, Nagoya, Aichi 4700195, Japan [36]Kurume Univ, Sch Med, Dept Med Biochem, Kurume, Fukuoka 8300011, Japan [37]Ehime Univ, Fac Collaborat Reg Innovat, Matsuyama, Ehime 7908577, Japan [38]Ehime Univ, Grad Sch Med, Dept Geriatr Med, Toon, Ehime 7910295, Japan [39]Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA [40]Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27516 USA [41]Chinese Natl Human Genome Ctr, Shanghai MOST Key Lab Hlth & Dis Genom, Dept Genet, Shanghai 201203, Peoples R China [42]Shanghai Ind Technol Inst, Shanghai 201203, Peoples R China [43]Univ San Carlos, USC Off Populat Studies Fdn, Cebu 6000, Philippines [44]Univ San Carlos, Dept Anthropol Sociol & Hist, Cebu 6000, Philippines [45]Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore [46]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 119228, Singapore [47]Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117597, Singapore [48]Merck Sharp Dohme Corp, Kenilworth, NJ 07033 USA [49]Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA [50]Univ Pittsburgh, UPMC Hillman Canc, Div Canc Control & Populat Sci, Pittsburgh, PA 15232 USA [51]Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore 169857, Singapore [52]Hebrew Univ Jerusalem, Hadassah Braun Sch Publ Hlth, Unit Epidemiol, POB 12272, Jerusalem, Israel [53]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China [54]Univ Oxford, Nuffield Dept Populat Hlth, MRC Populat Hlth Res Unit, Oxford OX3 7LF, England [55]Chinese Acad Med Sci, Beijing 100006, Peoples R China [56]Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China [57]Imperial Coll London, Dept Epidemiol & Biostat, London SW7 2AZ, England [58]Imperial Coll London, Natl Heart & Lung Inst, London SW7 2AZ, England [59]Imperial Coll London, Fac Med, Med Res Council Publ Hlth England MRC PHE Ctr Env, Dept Epidemiol & Biostat,Sch Publ Hlth, London SW7 2AZ, England [60]Imperial Coll London, Imperial Coll Biomed Res Ctr, London SW7 2AZ, England [61]Imperial Coll London, UK Dementia Res Inst, London SW7 2AZ, England [62]Natl Inst Hlth Res NIHR Hlth Protect Res Unit Hlt, London SW7 2AZ, England [63]Hlth Data Res UK London, London, England [64]Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands [65]Iwate Tohoku Med Megabank Org, Yahaba, Iwate 0283694, Japan [66]Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, D-68167 Mannheim, Germany [67]Tulane Univ, Sch Med, Dept Med, New Orleans, LA 70112 USA [68]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore 119228, Singapore [69]Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ Childrens Med Inst, Singapore 119228, Singapore [70]Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 119077, Singapore [71]Shimane Univ, Fac Med, Dept Funct Pathol, Izumo, Shimane 6930021, Japan [72]Aichi Gakuin Univ, Sch Dent, Dept Genome Sci, Nagoya, Aichi 4648650, Japan [73]Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto 6068501, Japan [74]RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan
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摘要:
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP ( max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

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出版当年[2017]版:
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2023]版:
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
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出版当年[2016]版:
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版:
Q1 MULTIDISCIPLINARY SCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者:
第一作者机构: [1]Natl Ctr Global Hlth & Med, Med Genom Ctr, Tokyo 1628655, Japan [2]Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo 1628655, Japan
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通讯作者:
通讯机构: [1]Natl Ctr Global Hlth & Med, Med Genom Ctr, Tokyo 1628655, Japan [2]Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo 1628655, Japan
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