Gastric cancer is the fourth most common type of cancer. Liver-intestine cadherin (CDH17) has been found to be involved in the proliferation and apoptosis of gastric cancer cells. Cisplatin is one of the most widely used antineoplastic agents in the treatment of solid tumor and hematological malignancies. However, the mechanism of enhancing cisplatin-inducing effects on human gastric cancer BGC823 cells by blocking CDH17 gene, both in vitro and in vivo, remains to be clarified. In this study, we investigated the signaling pathway by which cisplatin induces apoptosis by blocking CDH17 gene in gastric cancer BGC823 cells. Our results indicate that down-expression of CDH17 gene can enhance apoptosis-inducing effects of cisplatin on human gastric cancer BGC823 cells. The expression levels of Bax and Cyt-c proteins were upregulated, but the expression levels of Bcl-2 and Bcl-xL proteins were downregulated by blocking CDH17 gene in gastric cancer BGC823 cells after treatment with cisplatin. Moreover, down-expression of CDH17 enhanced the efficacy of cisplatin-induced inhibition of tumor growth in nude mice via apoptosis induction. Down-expression of CDH17 gene can significantly improve apoptosis-inducing effects of cisplatin in vitro and in vivo, which is a new strategy to improve chemotherapeutic effects on gastric cancer.
基金：
Wuhan Science and Technology Bureau [2015060101010064]; Hubei Province Natural Science Foundation of ChinaNatural Science Foundation of Hubei Province [2013CFB358]; Project of Health and Family Planning Commission of Wuhan Municipality [WX15C09, WX14C18]
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区生物工程与应用微生物3 区遗传学3 区医学：研究与实验4 区肿瘤学
最新[2025]版：
大类|3 区医学
小类|3 区生物工程与应用微生物3 区遗传学3 区医学：研究与实验4 区肿瘤学
JCR分区：
出版当年[2016]版：
Q1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ2ONCOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTALQ2GENETICS & HEREDITY
最新[2023]版：
Q1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ1GENETICS & HEREDITYQ1MEDICINE, RESEARCH & EXPERIMENTALQ1ONCOLOGY
第一作者机构：[1]Wuhan Univ, Dept Gastroenterol, Tongren Hosp, Wuhan Hosp 3, Wuhan 430060, Hubei, Peoples R China
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推荐引用方式(GB/T 7714)：
Liu Meng,Han Zheng,Zhu Qing-Xi,et al.Downregulation of liver-intestine cadherin enhances cisplatin-induced apoptosis in human gastric cancer BGC823 cells[J].CANCER GENE THERAPY.2018,25(1-2):doi:10.1038/s41417-017-0001-2.
APA：
Liu, Meng,Han, Zheng,Zhu, Qing-Xi,Tan, Jie,Liu, Wei-Jie...&Huang, Xiaodong.(2018).Downregulation of liver-intestine cadherin enhances cisplatin-induced apoptosis in human gastric cancer BGC823 cells.CANCER GENE THERAPY,25,(1-2)
MLA：
Liu, Meng,et al."Downregulation of liver-intestine cadherin enhances cisplatin-induced apoptosis in human gastric cancer BGC823 cells".CANCER GENE THERAPY 25..1-2(2018)
