Particulate matter ( PM) air pollution has been associated with an increase in the incidence of chronic allergic diseases; however, the mechanisms underlying the effect of exposure to natural ambient air pollution in chronic allergic diseases have not been fully elucidated. In the present study, we aimed to investigate the cellular responses induced by exposure to natural ambient air pollution, employing a mouse model of chronic allergy. The results indicated that exposure to ambient air pollution significantly increased the number of eosinophils in the nasal mucosa. The modulation of gene expression profile identified a set of regulated genes, and the Triggering Receptor Expressed on Myeloid cells1(TREM1) signaling canonical pathway was increased after exposure to ambient air pollution. In vitro, PM2.5 increased Nucleotide-binding oligomerization domain-containing protein 1 (Nod1) and nuclear factor (NF)-kappa B signaling pathway activation in A549 and HEK293 cell cultures. These results suggest a novel mechanism by which, PM2.5 in ambient air pollution may stimulate the innate immune system through the PM2.5-Nod1-NF-kappa B axis in chronic allergic disease.
基金：
program for National Key R&D
Program of China (2016YFC20160905200), the program for Changjiang Scholars and Innovative Research Team
(IRT13082); the National Natural Science Foundation of China (81371104, 81420108009, 81570895, 81400444,
81470678 and 81630023); Beijing health bureau program for high level talents (2014–3–017); Beijing Municipal
Administration of Hospitals’ Mission Plan (SML20150203); Japan Society for the Promotion of Science (JSPS),
Grant-in-Aid for Challenging Exploratory Research (26650159); Program for Tongjiang Scholars and Fujian
Natural Science Foundation (2017J01152); The Program for Fujian Collaborative Innovation Center.
第一作者机构：[1]Capital Univ Med Sci, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China[2]Capital Univ Med Sci, Beijing TongRen Hosp, Dept Allergy, Beijing 100730, Peoples R China[3]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing 100005, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Univ Med Sci, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China[2]Capital Univ Med Sci, Beijing TongRen Hosp, Dept Allergy, Beijing 100730, Peoples R China[3]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Ouyang Yuhui,Xu Zhaojun,Fan Erzhong,et al.Changes in gene expression in chronic allergy mouse model exposed to natural environmental PM2.5-rich ambient air pollution[J].SCIENTIFIC REPORTS.2018,8:doi:10.1038/s41598-018-24831-z.
APA：
Ouyang, Yuhui,Xu, Zhaojun,Fan, Erzhong,Li, Ying,Miyake, Kunio...&Zhang, Luo.(2018).Changes in gene expression in chronic allergy mouse model exposed to natural environmental PM2.5-rich ambient air pollution.SCIENTIFIC REPORTS,8,
MLA：
Ouyang, Yuhui,et al."Changes in gene expression in chronic allergy mouse model exposed to natural environmental PM2.5-rich ambient air pollution".SCIENTIFIC REPORTS 8.(2018)
