机构：[1]Department of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, China[2]Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China[3]Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Drug resistance is a major cause of treatment failure in pancreatic cancer. The limited evidence indicates the involvement of miR-455-3p in chemotherapy resistance of cancer. Here we observed by qPCR that miR-455-3p was significantly decreased in pancreatic cancer tissues and cell lines. We then confirmed that the inhibition of miR-455-3p increased cell proliferation and gemcitabine resistance of pancreatic cancer, whereas forced overexpression of miR-455-3p had the opposite effect. Furthermore, we demonstrated that TAZ, which is associated with drug resistance of pancreatic cancer, is a new direct downstream target of miR-455-3p. Our present study suggests that miR-455-3p contributes to cell proliferation and drug resistance in pancreatic cancer cells via targeting TAZ.
基金：
National Natural Science
Foundation of China (31371368 and 81671540 to Y.Z.), the Natural
Science Foundation of Hubei Province in China (2013CFA060 to
Y.Z. and 2015BHE022 to X.H.), the Commission for Science and
Technology of Wuhan Municipality (2014070504020245 to Y.Z.),
and the China Guanghua Science and Technology Foundation
(2014093 to Y.Z.).
第一作者机构：[1]Department of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, China[2]Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China[3]Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China
共同第一作者：
通讯作者：
通讯机构：[2]Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China[*1]The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory for Molecular Diagnosis of Hubei Province, 26 Shengli Street, Wuhan 430014, China.
推荐引用方式(GB/T 7714)：
Zhan Ting,Huang Xiaodong,Tian Xia,et al.Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ[J].MOLECULAR THERAPY-NUCLEIC ACIDS.2018,10:215-226.doi:10.1016/j.omtn.2017.12.002.
APA：
Zhan, Ting,Huang, Xiaodong,Tian, Xia,Chen, Xiaoli,Ding, Yu...&Zhang, Yadong.(2018).Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ.MOLECULAR THERAPY-NUCLEIC ACIDS,10,
MLA：
Zhan, Ting,et al."Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ".MOLECULAR THERAPY-NUCLEIC ACIDS 10.(2018):215-226
医学