机构：[1]Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA[2]Department of Genetic Epidemiology, University of Regensburg,Regensburg 93051, Germany[3]Cardiovascular Division, Department of Medicine,Washington University, St. Louis, MO 63110, USA[4]Center forResearch on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA[5]Department of Epidemiology,Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA[6]Division of Statistical Genomics,Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA[7]William Harvey Research Institute, Clinical Pharmacology,Queen Mary University of London, London EC1M 6BQ, UK[8]Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA MedicalCenter, Torrance, CA 90502, USA[9]Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC27514, USA[10]Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA[11]SingaporeEye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore[12]Ophthalmology & Visual Sciences Academic ClinicalProgram (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore[13]Department of Ophthalmology, Yong Loo Lin School of Medicine,National University of Singapore, Singapore, Singapore 117597, Singapore[14]Saw Swee Hock School of Public Health, National University HealthSystem and National University of Singapore, Singapore, Singapore 117549, Singapore[15]Department of Epidemiology, Erasmus University Medical Center,Rotterdam, the Netherlands[16]Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, EdinburghEH4 2XU, UK[17]Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA[18]Department ofEpidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, GA 30602, USA[19]Section of Metabolic Genetics, NovoNordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark[20]Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA[21]Brown FoundationInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA[22]Department of Internal Medicine,Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300RC, the Netherlands[23]Department of Epidemiology, University ofAlabama at Birmingham, Birmingham, AL 35294, USA[24]Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA[25]Centrede Bioinformatique Biostatistique et Biologie Integrative (C3BI), Institut Pasteur, Paris 75015, France[26]Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA 98101, USA[27]Genome Institute of Singapore, Agency for Science Technology and Research,Singapore 138672, Singapore[28]Division of Biostatistical Sciences, Department of Public Health Sciences,Wake Forest School of Medicine,Winston-Salem,NC 27157, USA[29]Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA 02114, USA[30]Program in Medical and PopulationGenetics, Broad Institute of MITand Harvard, Cambridge, MA02142, USA[31]Human Genomics Laboratory, Pennington Biomedical Research Center, BatonRouge, LA 70808, USA[32]Icelandic Heart Association, Kopavogur 201, Iceland[33]Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland[34]Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224,USA[35]Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA[36]NIHR Cardiovascular Biomedical Research Unit,Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK[37]School of Public Health, Departmentof Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA[38]Department of Biostatistics, Boston University School of Public Health, Boston,MA 02118, USA[39]Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan[40]Department ofBiostatistics, University of Washington, Seattle, WA 98105, USA[41]Estonian Genome Center, University of Tartu, Tartu 51010, Estonia[42]Department ofEpidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands[43]CNRS UMR 8199, EuropeanGenomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France[44]Saw Swee Hock School of Public Health, NationalUniversity of Singapore, Singapore 117549, Singapore[45]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177,Sweden[46]Department of Medical Sciences, University of Trieste, Trieste 34137, Italy[47]Department of Molecular Genetics and Genomics Program, WakeForest School of Medicine,Winston-Salem, NC 27157, USA[48]Division of Preventive Medicine, Department of Medicine, Brigham andWomen’s Hospital,Boston, MA 02215, USA[49]Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU,UK[50]Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK[51]Centre for Cognitive Ageing and Cognitive Epidemiology, TheUniversity of Edinburgh, Edinburgh EH8 9JZ, UK[52]Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicineand MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh EH4 2XU, UK[53]Postgraduate Program in Epidemiology,Federal University of Pelotas, Pelotas, RS 96020220, Brazil[54]Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, Universityof Sao Paulo, Sao Paulo, Brazil[55]Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA[56]Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland[57]Department of ClinicalPhysiology, Tampere University Hospital, Tampere, Finland[58]Department of Public Health, University of Kelaniya, Ragama, Sri Lanka[59]Research Unitof Molecular Epidemiology, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg 85764, Germany[60]Instituteof Epidemiology II, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg 85764, Germany[61]Institute of EnvironmentalMedicine, Karolinska Institutet, Stockholm 17177, Sweden[62]Department of Medical Research, Taichung Veterans General Hospital, Departmentof Social Work, Tunghai University, Taichung 40705, Taiwan[63]Department of Opthalmology, Taichung Veterans General Hospital, Taichung40705, Taiwan[64]MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK[65]Tropical Metabolism Research Unit, Tropical MedicineResearch Institute, University of theWest Indies, Mona JMAAW15, Jamaica[66]Department of Occupational and Environmental Health and State Key Laboratoryof Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology,Wuhan,China[67]Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK[68]NIHR Leicester Cardiovascular Biomedical Research Unit,Glenfield Hospital, Leicester LE3 9QP, UK[69]Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine,Kuopio 70100, Finland[70]Taub Institute for Research on Alzheimer disease and the Aging Brain, Department of Epidemiology, Columbia UniversityMailman School of Public Health, New York, NY 10032, USA[71]Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans GeneralHospital, Taichung 40705, Taiwan[72]School of Medicine, National Yang-ming University, Taipei, Taiwan[73]School of Medicine, National Defense MedicalCenter, Taipei, Taiwan[74]Institute of Medical Technology, National Chung-Hsing University, Taichung 40705, Taiwan[75]Institute of Clinical Medicine,Internal Medicine, University of Eastern Finland, Kuopio 70210, Finland[76]Department of Gene Diagnostics and Therapeutics, Research Institute, NationalCenter for Global Health and Medicine, Tokyo 1628655, Japan[77]Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University,Malmo¨, Ska°ne 205 02, Sweden[78]Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA[79]Institute for Social Research, Research Center for Group Dynamics, University of Michigan, Ann Arbor, MI 48104, USA[80]Interfaculty Institute for Geneticsand Functional Genomics, University Medicine and Ernst-Moritz Arndt University Greifswald, Greifswald 17487, Germany[81]DZHK (German Centerfor Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany[82]Division of Epidemiology, Department of Medicine, VanderbiltUniversity School of Medicine, Nashville, TN 37203, USA[83]General Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns HopkinsUniversity School of Medicine, Baltimore, MD 21287, USA[84]Department of Epidemiology and Biostatistics, Imperial College London, London W21PG, UK[85]Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK[86]McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins UniversitySchool of Medicine, Baltimore,MD 21205, USA[87]Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USA[88]Human Genetics Center, The University of Texas School of Public Health, Houston, TX 77030, USA[89]Institute of Molecular Medicine, TheUniversity of Texas Health Science Center, Houston, TX 77030, USA[90]Cardiovascular Health Research Unit, Medicine, University ofWashington, Seattle,WA 98101, USA[91]Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI53226, USA[92]Sleep Medicine and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115, USA[93]Centre for Genomic & ExperimentalMedicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK[94]Center for Complex Disease Genomics,McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA[95]Centre for Brain Research,Indian Institute of Schience, Bangalore 560012, India[96]The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark,Odense, Denmark[97]Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA[98]Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK[99]Department of Clinical Epidemiology, Leiden University MedicalCenter, Leiden 2300RC, the Netherlands[100]Department of Medicine, University of Kelaniya, Ragama, Sri Lanka[101]Inserm U1219 Neuroepidemiology,University of Bordeaux, Bordeaux, France[102]Department of Neurology, University Hospital, Bordeaux, France[103]Boston University School of Medicine,Boston, MA 02118, USA[104]Department of Internal Medicine B, University Medicine Greifswald, Greifswald 17475, Germany[105]Department of Genetics,University of North Carolina, Chapel Hill, NC 27514, USA[106]Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University,Providence, RI 02860, USA[107]Division of Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Geneva 1211, Switzerland[108]Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece[109]Institute for Social Research, SurveyResearch Center, University of Michigan, Ann Arbor, MI 48104, USA[110]Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem91120, Israel[111]MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, ImperialCollege London, London, UK[112]Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for CardiovascularDiseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[113]Department of Psychology, The Universityof Edinburgh, Edinburgh EH8 9JZ, UK[114]Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda,MD20892,USA[115]Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA[116]Department ofMedicine, Tulane University School of Medicine, New Orleans, LA 70112, USA[117]University of Eastern Finland, Institute of Biomedicine, Kuopio 70211,Finland[118]Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore[119]Khoo TeckPuat – National University Children’s Medical Institute, National University Health System, Singapore 119228, Singapore[120]Laboratory of Genome Technology,Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku 108-8639, Japan[121]MedStar Health Research Institute,Hyattsville, MD 20782, USA[122]Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington,DC 20057, USA[123]Cardiovascular Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USA[124]Weill CornellMedicine in Qatar, Doha, Qatar[125]Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USA[126]Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA[127]Department of Clinical Gene Therapy, OsakaUniversity Graduate School of Medicine, Suita 5650871, Japan[128]Department of Geriatric and General Medicine, Osaka University Graduate School ofMedicine, Suita 5650871, Japan[129]Epidemiology, Department of Occupational and Environmental Medicine Program, University ofWashington, Seattle,WA 98105, USA[130]Department of Biochemistry, National University of Singapore, Singapore 117596, Singapore[131]Duke-NUS Medical School, Singapore169857, Singapore[132]Department of Health, National Institute for Health andWelfare, Helsinki 00271, Finland[133]Department of Medicine and AbdominalCenter: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland[134]Fred Hutchinson Cancer ResearchCenter, University of Washington School of Public Health, Seattle, WA 98109, USA[135]Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan[136]Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland[137]Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA[138]Lifelines cohort study, University of Groningen, UniversityMedical Center Groningen, Groningen 9700 RB, the Netherlands[139]WHI CCC, Fred Hutchinson Cancer Research Center, Seattle,WA 98115, USA[140]Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA[141]Translational Laboratory in Genetic Medicine,Agency for Science, Technology and Research 138648, Singapore[142]Institute of Human Genetics, Helmholtz ZentrumMu¨nchen, German Research Centerfor Environmental Health, Neuherberg 85764, Germany[143]Institute of Human Genetics, Technische Universita¨t Mu¨nchen, Munich 80333, Germany[144]Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan[145]Department of Biostatistics,University of Liverpool, Liverpool L69 3GL, UK[146]Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson,MS 39216, USA[147]Mathematical and Statistical Computing Laboratory, Center for Information Technology, NIH, Bethesda, MD 20892, USA[148]The Institute of MedicalSciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen AB25 2ZD, UK[149]Data Tecnica International, Glen Echo, MD 20812,USA[150]Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA[151]Department of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, USA[152]Department of Medicine, University of Ibadan, Ibadan, Nigeria[153]Institute of Cardiovascular and Medical Sciences,University of Glasgow, Glasgow G12 8TA, UK[154]Internal Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA[155]Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA[156]Division of Epidemiology and Community Health,University of Minnesota School of Public Health, Minneapolis, MN 55454, USA[157]DZHK (German Centre for Cardiovascular Research), partner site MunichHeart Alliance, Neuherberg 85764, Germany[158]Faculty of Medicine, University of Split, Split, Croatia[159]Department of Clinical Physiology and NuclearMedicine, Turku University Hospital, Turku 20521, Finland[160]Research Centre of Applied and Preventive Cardiovascular Medicine, University ofTurku, Turku 20520, Finland[161]Department of Biobank Research, Umea° University, Umea°, Va¨sterbotten 901 87, Sweden[162]Medical Genetics, IRCCSBurlo, Garofolo 34137, Italy[163]Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, USA[164]Usher Institute of PopulationHealth Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK[165]Institute for Community Medicine, University Medicine Greifswald,Greifswald 17475, Germany[166]National Heart and Lung Institute, Imperial College London, London W12 0NN, UK[167]Department of Neurology,Boston University School of Medicine, Boston, MA 02118, USA[168]International Centre for Circulatory Health, Imperial College London, London W2 1PG,UK[169]Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh EH8 9JZ, UK[170]Institute of Genetic Epidemiology, HelmholtzZentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg 85764, Germany[171]Chair of Genetic Epidemiology, IBE, Facultyof Medicine, LMU Munich, Munich 81377, Germany[172]Department of Genetics, Stanford University, Stanford, CA 94305, USA[173]Life Sciences Institute,National University of Singapore, Singapore, Singapore 117456, Singapore[174]NUS Graduate School for Integrative Science and Engineering, NationalUniversity of Singapore, Singapore 117456, Singapore[175]Department of Statistics and Applied Probability, National University of Singapore, Singapore117546, Singapore[176]Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands[177]Beijing Institute of Ophthalmology,Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China 100730, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[178]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[179]Jackson Heart Study, Department of PublicHealth, Jackson State University, Jackson, MS 39213, USA[180]Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh,Pittsburgh, PA 15261, USA[181]Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232,USA[182]Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD21224, USA[183]Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, MA 02142, USA[184]Harvard T.H. Chan Schoolof Public Health, Department of Nutrition, Harvard University, Boston, MA 02115, USA[185]Department of Public Health & Clinical Medicine, Umea° University,Umea°, Va¨sterbotten 901 85, Sweden[186]Division of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA[187]Department of Genomics of Common Disease, Imperial College London, London W12 0NN, UK[188]Division ExperimentalGenetics, Sidra, Doha 26999, Qatar[189]German Center for Diabetes Research (DZD e.V.), Neuherberg 85764, Germany[190]Endocrinology and Metabolism,Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taipei 11490, Taiwan[191]Department of Ophthalmology, Medical Faculty Mannheim,University Heidelberg, Mannheim 68167, Germany[192]Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland[193]Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Lifes Sciences, University of Tampere,Tampere 33014, Finland[194]Cardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan[195]Department of Medicine, China MedicalUniversity, Taichung 40705, Taiwan[196]Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen 9700RB, the Netherlands[197]Genetics, Harvard Medical School, Boston, MA 02115, USA[198]Institute of Physiology, University Medicine Greifswald, Greifswald17495, Germany[199]Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands[200]Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA[201]Sticht Center for Health Aging and Alzheimer’sPrevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA[202]Population Sciences Branch,Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA[203]Division of Endocrinology, Diabetes, andNutrition, University of Maryland School of Medicine, Baltimore,MD21201, USA[204]Program for Personalized and GenomicMedicine, University of MarylandSchool of Medicine, Baltimore, MD 21201, USA[205]Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University ofWashington, Seattle, WA 98101, USA[206]Kaiser Permanente Washington, Health Research Institute, Seattle, WA 98101, USA[207]Department of Medicine,Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore[208]Dean’s Office, University of Kentucky College of PublicHealth, Lexington, KY 40536, USA[209]Department of Public Health and Primary Care, Leiden University Medical Center, Leiden 2300RC, theNetherlands[210]Cardiology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA[211]Icahn School of Medicineat Mount Sinai, The Mindich Child Health and Development Institute, New York, NY 10029, USA[212]Genomic Outcomes, Department of Medicine,LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA[213]Department of Psychiatry,Washington University School of Medicine, St. Louis,MO 63110, USA[214]Division of Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90032, USA[215]NIHRBarts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined similar to 18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 x 10(-8)) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 x 10(-8)). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling MSRA, EBF2).
基金：
U.S. National Heart, Lung, and Blood Institute (NHLBI)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI); National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01HL118305]; NHLBIUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [K25HL121091]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P01CA196569] Funding Source: NIH RePORTER; NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR001881] Funding Source: NIH RePORTER; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R21HL123677, U01HL130114, T32HL007055, R00HL130580, K25HL121091, R01HL117078, K01HL135405, R01HL105756, R01HL118305] Funding Source: NIH RePORTER; NATIONAL HUMAN GENOME RESEARCH INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Human Genome Research Institute (NHGRI) [ZIAHG200362, ZIAHG000024] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01DK062370, P30DK063491, U01DK062370, P30DK072488, P30DK020572] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [U54GM115428] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [U01AG023746, R01AG054076, U01AG009740] Funding Source: NIH RePORTER; National Institute on Minority Health and Health DisparitiesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Minority Health & Health Disparities (NIMHD) [R01MD012765] Funding Source: NIH RePORTER; MRCUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [G0601966, G0700931, MR/K002414/1, MR/R023484/1, UKDRI-5001, MC_UU_00007/10, MC_UU_12015/1, MC_UP_1605/7, MR/L01632X/1, MR/L01341X/1, G0600237, MC_PC_U127561128, MC_UU_12015/5, G9521010] Funding Source: UKRI; British Heart FoundationBritish Heart Foundation [SP/13/2/30111] Funding Source: researchfish; Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission [MR/K006584/1, MR/K026992/1, MC_UP_1605/7, MC_PC_13048, MR/L01341X/1, UKDRI-5001, MC_UU_12015/5, G0700931, MR/L01632X/1, HDR-2002, G0600237, MC_UU_12015/1, MC_UU_00007/10, MR/R023484/1, G0601966, MC_PC_13046, MR/K002414/1, G9521010, MC_PC_U127561128, G0700704B] Funding Source: researchfish; National Institute for Health ResearchNational Institute for Health Research (NIHR) [NF-SI-0617-10149, NF-SI-0611-10136, NF-SI-0512-10113, NF-SI-0512-10135, NF-SI-0617-10154, NF-SI-0513-10059] Funding Source: researchfish; NNF Center for Basic Metabolic ResearchNovo Nordisk Foundation [Kilpel�inen Group] Funding Source: researchfish
第一作者机构：[1]Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yun J. Sung,Thomas W. Winkler,Lisa de las Fuentes,et al.A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure[J].AMERICAN JOURNAL OF HUMAN GENETICS.2018,102(3):375-400.doi:10.1016/j.ajhg.2018.01.015.
APA：
Yun J. Sung,Thomas W. Winkler,Lisa de las Fuentes,Amy R. Bentley,Michael R. Brown...&Daniel I. Chasman.(2018).A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.AMERICAN JOURNAL OF HUMAN GENETICS,102,(3)
MLA：
Yun J. Sung,et al."A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure".AMERICAN JOURNAL OF HUMAN GENETICS 102..3(2018):375-400
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