Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia
机构：[1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China,临床科室麻醉科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Research Center for Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, China,[3]The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China,[4]Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,[5]Department of Radiology, Beijing Tongren Hospital, Beijing, China,医技科室放射科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[6]School of Biomedical Engineering, Capital Medical University, Beijing, China,[7]Sleep Medical Center, Department of Laryngology, Beijing Tongren Hospital, Beijing, China,首都医科大学附属北京同仁医院临床科室耳鼻咽喉-头颈外科咽喉科[8]Beijing Shijitan Hospital, Capital Medical University, Beijing, China
Background The mechanism of general anesthesia (GA) has been explored for hundreds of years, but unclear. Previous studies indicated a possible correlation between NREM sleep and GA. The purpose of this study is to compare them by in vivo human brain function to probe the neuromechanism of consciousness, so as to find out a clue to GA mechanism. Methods 24 healthy participants were equally assigned to sleep or propofol sedation group by sleeping ability. EEG and Ramsay Sedation Scale were applied to determine sleep stage and sedation depth respectively. Resting-state functional magnetic resonance imaging (RS-fMRI) was acquired at each status. Regional homogeneity (ReHo) and seed-based whole brain functional connectivity maps (WB-FC maps) were compared. Results During sleep, ReHo primarily weakened on frontal lobe (especially preoptic area), but strengthened on brainstem. While during sedation, ReHo changed in various brain areas, including cingulate, precuneus, thalamus and cerebellum. Cingulate, fusiform and insula were concomitance of sleep and sedation. Comparing to sleep, FCs between the cortex and subcortical centers (centralized in cerebellum) were significantly attenuated under sedation. As sedation deepening, cerebellum-based FC maps were diminished, while thalamus-and brainstem-based FC maps were increased. Conclusion There're huge distinctions in human brain function between sleep and GA. Sleep mainly rely on brainstem and frontal lobe function, while sedation is prone to affect widespread functional network. The most significant differences exist in the precuneus and cingulate, which may play important roles in mechanisms of inducing unconciousness by anesthetics.
基金：
National Science and Technology Pillar Program of China [2012BAI05B03]; National Natural Science Foundation of China (NSFC) [81171422, 61271151, 91520202]; Youth Innovation Promotion Association CAS
第一作者机构：[1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China,[8]Beijing Shijitan Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Li Yun,Wang Shengpei,Pan Chuxiong,et al.Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia[J].PLOS ONE.2018,13(2):doi:10.1371/journal.pone.0192358.
APA：
Li, Yun,Wang, Shengpei,Pan, Chuxiong,Xue, Fushan,Xian, Junfang...&He, Huiguang.(2018).Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia.PLOS ONE,13,(2)
MLA：
Li, Yun,et al."Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia".PLOS ONE 13..2(2018)
