机构:[1]Department of Otolaryngology Head and Neck Surgery and Department of allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室耳鼻咽喉-头颈外科变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Purpose: Chinese herbal medicine (CHM) has been widely used in China to treat allergic rhinitis (AR). However, several studies have produced conflicting data with regard to the efficacy of the medicine. Our aim was to perform a meta-analysis of randomized clinical trials (RCTs) to evaluate the relative efficacy of CHM. Methods: We systematically searched the PubMed, Medline, and Springer electronic databases up to March 2017 for RCTs comparing the efficacy of CHM versus placebo for the treatment of patients with AR. Total nasal symptoms and quality of life were assessed through pooling mean difference (MD) with its 95% confidence interval (CI). Moreover, sensitivity and subgroup analyses according to control design and quality of life assessment were performed to evaluate the source of heterogeneity. Results: Eleven RCTs were enrolled in the meta-analysis. Assessment of overall heterogeneity indicated significant heterogeneity among the individual studies (l(2)=100%, P<0.00001), and thus ransomed effects model was used to pool data. CHM was found to significantly enhance quality of life compared with placebo (MD=-0.88, [95% CI: -1.55, -0.21]; P=0.01). The symptom of itchy nose, sneezing or total nasal symptoms scores were not significantly improved after CHM treatment, although the improvement in itchy nose just failed to reach significance (MD=0.09, (95% CI: 0.00, 0.18); P=0.06). Conclusions: This study suggests that CHM appears to improve the quality of life of AR patients. However, these findings, as well as the findings for the effect of CHM on sneezing, total nasal symptoms, and the symptom of itchy nose, need to be substantiated in larger cohorts of AR patients by further well-designed studies.
基金:
National Key R & D Program of China (2016YFC20160905200), the Program for Changjiang Scholars and Innovative Research Team (IRT13082), the National Natural Science Foundation of China (81420108009 and 81630023), the special fund of capital health development (2011-1017-06, 2011-1017-02), the special fund of sanitation elite reconstruction of Beijing (2009-2-007), Beijing health bureau program for high level talents (2011-3-043 and 2014-3-018),Beijing Municipal Administration of Hospitals’ Mission Plan (SML20150203), Beijing Natural Science Foundation (7164247 and 7172053), the Capital Research Funds for Medical Development (2016-4-1092) and the priming scientific research foundation for the junior researcher in Beijing TongRen Hospital (2015-YJJ-ZZL-010).
第一作者机构:[1]Department of Otolaryngology Head and Neck Surgery and Department of allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
通讯作者:
通讯机构:[1]Department of Otolaryngology Head and Neck Surgery and Department of allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China[*1]Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, China
推荐引用方式(GB/T 7714):
Zhang Xu,Lan Feng,Zhang Yuan,et al.Chinese Herbal Medicine to Treat Allergic Rhinitis: Evidence From a Meta-Analysis[J].ALLERGY ASTHMA & IMMUNOLOGY RESEARCH.2018,10(1):34-42.doi:10.4168/aair.2018.10.1.34.
APA:
Zhang, Xu,Lan, Feng,Zhang, Yuan&Zhang, Luo.(2018).Chinese Herbal Medicine to Treat Allergic Rhinitis: Evidence From a Meta-Analysis.ALLERGY ASTHMA & IMMUNOLOGY RESEARCH,10,(1)
MLA:
Zhang, Xu,et al."Chinese Herbal Medicine to Treat Allergic Rhinitis: Evidence From a Meta-Analysis".ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 10..1(2018):34-42