机构：[1]Fudan Univ, Shanghai Resp Res Inst, Zhongshan Hosp, Dept Pulm Med, Shanghai, Peoples R China[2]Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA USA[3]Shanghai Jiao Tong Univ, Dept Pulm Med, Tongren Hosp, Shanghai, Peoples R China
IntroductionBronchiectasis is a common disabling respiratory disease in China. However, the literatures that focused on the long-term prognosis and the risk factors for mortality are limited. ObjectiveThe aim of this study was to identify risk factors for 5-year mortality in patients with bronchiectasis. MethodsA retrospective study was conducted. Patients who were newly diagnosed with bronchiectasis by thoracic conventional CT scans from January 2003 to March 2008 were assessed. Baseline characteristics, symptoms, radiographic extent, pulmonary function tests data and comorbidities were recorded through chart review. The vital status of the patients was obtained by telephone contact and record of hospital admission. Multivariate cox regression analysis was used to determine the independent risk factors for 5-year mortality. ResultsEighty-nine patients newly diagnosed with bronchiectasis were included in our cohort. The mean age of the cohort was 55.2916.15 and 49.4% of the patients were female. At the end of the study, 12 patients (13.5%) died and the mean survival time was 57.05 +/- 1.09 months. Multivariate analysis revealed that long-term mortality was significantly associated with emphysema (HR, 5.62; 95% confidence interval [CI], 1.35-23.46; P=0.02) and radiographic extent (HR, 1.62; 95% CI, 1.02-2.58; P=0.04). ConclusionThe main finding of our study was that emphysema might be a risk factor for mortality in patients with bronchiectasis.
基金：
Shanghai Leading Academic Discipline ProjectShanghai Leading Academic Discipline Project [B115]; National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170056, 81400018, 81400002, 30930090]; Shanghai Committee of Science and TechnologyShanghai Science & Technology Committee [11411951102, 12JC1402300]; Academic Special Science and Research Foundation for PhD Education [20130071110044]; National Key Technology R&D Program of the 12th National Five-year Development PlanNational Key Technology R&D Program [2012BAI05B01]; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
第一作者机构：[1]Fudan Univ, Shanghai Resp Res Inst, Zhongshan Hosp, Dept Pulm Med, Shanghai, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Fudan Univ, Shanghai Resp Res Inst, Zhongshan Hosp, Dept Pulm Med, Shanghai, Peoples R China[3]Shanghai Jiao Tong Univ, Dept Pulm Med, Tongren Hosp, Shanghai, Peoples R China[*1]Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai Respiratory Research Institute, Shanghai, People’s Republic of China[*2]Department of Pulmonary Medicine, Tongren Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China
推荐引用方式(GB/T 7714)：
Tang Xinjun,Bi Jing,Yang Dawei,et al.Emphysema is an independent risk factor for 5-year mortality in patients with bronchiectasis[J].CLINICAL RESPIRATORY JOURNAL.2017,11(6):887-894.doi:10.1111/crj.12432.
APA：
Tang, Xinjun,Bi, Jing,Yang, Dawei,Chen, Shujing,Li, Zhuozhe...&Song, Yuanlin.(2017).Emphysema is an independent risk factor for 5-year mortality in patients with bronchiectasis.CLINICAL RESPIRATORY JOURNAL,11,(6)
MLA：
Tang, Xinjun,et al."Emphysema is an independent risk factor for 5-year mortality in patients with bronchiectasis".CLINICAL RESPIRATORY JOURNAL 11..6(2017):887-894
