Purpose. To compare laser peripheral iridotomy (LPI) with trabeculectomy as an initial treatment for primary angle-closure glaucoma (PACG) with peripheral anterior synechiae (PAS) >= 6 clock hours. Methods. Patients were drawn from two randomized controlled trials. 38 eyes of 38 patients (PAS >= 6 clock hours) were treated with LPI (group 1) while 111 eyes of 111 PACG patients (PAS >= 6 clock hours) underwent primary trabeculectomy (group 2). All patients underwent a comprehensive ophthalmic examination at baseline and at postoperative visits and were followed up for a minimum of one year. Results. Group 2 had higher baseline IOP (45.7 +/- 14.8mmHg versus 34.3 +/- 14.3 mmHg) than group 1 and more clock hours of PAS (10.4 +/- 1.9 versus 9.0 +/- 2.2). IOPs at all postoperative visits were significantly lower in group 2 than in group 1 (p = 0 000). Five eyes in group 1 required trabeculectomy. 17 of the 38 eyes in group 1 (44.7%) required IOP-lowering medications as compared to seven of the 111 eyes in group 2 (6.3%). Cataract progression was documented in 2 eyes (5.3%) in group 1 and 16 eyes (14.4%) in group 2. Conclusions. Primary trabeculectomy for PACG (PAS >= 6 clock hours) is more effective than LPI in lowering IOP.
基金：
Beijing Science & Technology
Novel Star Program (2009B44), the National 11th Fiveyear
Plan Science and Technology Supporting Programs,
and the Ministry of Science and Technology of the People’s
Republic of China (Grant no. 2007BAI18B08). It was also
supported by the Research and Development Fund of
Wenzhou Medical University (QTJ13009).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区眼科学
最新[2023]版：
大类|4 区医学
小类|4 区眼科学
JCR分区：
出版当年[2015]版：
Q3MEDICINE, RESEARCH & EXPERIMENTALQ3OPHTHALMOLOGY
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Key Lab Ophthalmol & Visual Sci, Beijing, Peoples R China
通讯作者：
通讯机构：[3]Wenzhou Med Univ, Sch Optometry & Ophthalmol, Affiliated Eye Hosp, Wenzhou, Peoples R China[4]Queens Univ, Sch Med Dent & Biomed Sci Publ Hlth, Hlth Serv & Primary Care, Belfast, Antrim, North Ireland
推荐引用方式(GB/T 7714)：
Chen Yan Yun,Fan Su Jie,Liang Yuan Bo,et al.Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma[J].JOURNAL OF OPHTHALMOLOGY.2017,2017:doi:10.1155/2017/2761301.
APA：
Chen, Yan Yun,Fan, Su Jie,Liang, Yuan Bo,Rong, Shi Song,Meng, Hai Lin...&Wang, Ning Li.(2017).Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma.JOURNAL OF OPHTHALMOLOGY,2017,
MLA：
Chen, Yan Yun,et al."Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma".JOURNAL OF OPHTHALMOLOGY 2017.(2017)
