Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta 1/Smads and PI3K/Akt pathways
The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a characteristic response to acute or chronic liver injury. Mice were randomized to bile duct ligation (BDL) or carbon tetrachloride (CCl4) cirrhosis models. Quercetin (100 mg/kg or 200 mg/kg daily) was administered by gavage for 2 or 4 weeks. Liver tissue and blood samples were collected for histological and molecular analysis. The results of our experiments showed that quercetin reduced BDL or CCl4 liver fibrosis, inhibited extracellular matrix formation, and regulated matrix metallopeptidase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1. Quercetin attenuated liver damage by suppressing the TGF-beta 1/Smads signaling pathway and activating the PI3K/Akt signaling pathway to inhibit autophagy in BDL or CCl4- induced liver fibrosis. Quercetin prevented hepatic fibrosis by attenuating hepatic stellate cell activation and reducing autophagy through regulating crosstalk between the TGF-beta 1/Smads and PI3K/Akt pathways.
基金：
National Natural Science Foundation of China[81670472, 81500466]
第一作者机构：[1]Tongji Univ, Sch Med, Shanghai Tenth Peoples Hosp, Dept Gastroenterol, Shanghai 200072, Peoples R China
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推荐引用方式(GB/T 7714)：
Wu Liwei,Zhang Qinghui,Mo Wenhui,et al.Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta 1/Smads and PI3K/Akt pathways[J].SCIENTIFIC REPORTS.2017,7:doi:10.1038/s41598-017-09673-5.
APA：
Wu, Liwei,Zhang, Qinghui,Mo, Wenhui,Feng, Jiao,Li, Sainan...&Guo, Chuanyong.(2017).Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta 1/Smads and PI3K/Akt pathways.SCIENTIFIC REPORTS,7,
MLA：
Wu, Liwei,et al."Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta 1/Smads and PI3K/Akt pathways".SCIENTIFIC REPORTS 7.(2017)
